The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
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Department of Biochemistry |
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Mechanism of Action of Gepotidacin: Well-Balanced Dual-Targeting against Neisseria gonorrhoeae Gyrase and Topoisomerase IV in Cells and In Vitro. ACS Infectious Diseases.
Alexandria Oviatt*, Jessica Collins, Chelsea Mann, Neil Osheroff*. -
Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1 (preprint). bioRxiv.
Briana Greer*, Elwood Mullins, Emma Peacock, Sander Haigh, Carl Schiltz, David Cortez, Brandt Eichman*.
Supported by the Cryo-EM Facility. -
Identification of ligands for E3 ligases with restricted expression using fragment-based methods. RSC Chemical Biology.
Alex Waterson*, Brian Lehmann, Zhenwei Lu, John Sensintaffar, Edward Olejniczak, Bin Zhao, Tyson Rietz, William Payne, Jason Phan, Stephen Fesik*.
Supported by the High-Throughput Screening Facility, the Biomolecular NMR Facility. -
Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension. Journal of the American Chemical Society.
Dinh Nguyen* (University of Illinois at Urbana-Champaign), Mayuresh Gadgil, Douglas Mitchell*.
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Department of Cell and Developmental Biology |
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Integration of Elemental Imaging and Spatial Transcriptomic Profiling for Proof-of-Concept Metals-Based Pathway Analysis of Colon Tumor Microenvironment. Metallomics.
Aruesha Srivastava* (California Institute of Technology), Ken Lau. -
Pan-cancer analyses reveal disparities in tumor genomic profiles by race/ethnicity, age, and sex. Cancer Epidemiology Biomarkers & Prevention.
Wanqing Wen*, Bhuminder Singh, Kristen Ciombor, Ben Ho Park, Xiao-Ou Shu, Kamran Idrees, Wei Zheng, Xingyi Guo*.
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Department of Molecular Physiology and Biophysics |
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TrueSpot: a robust automated tool for quantifying signal puncta in fluorescent imaging. Genome Biology.
Blythe Hospelhorn*, Benjamin Kesler, Hossein Jashnsaz, Gregor Neuert*.
School of Medicine Basic Sciences: New algorithmic tool can improve microscopy image analysis, making improvements across fields -
A conserved mechanism of LRRC8 channel inhibition by two structurally distinct drugs. Communications Biology.
Toshiki Yamada*, Paola Bisignano, Erkan Karakas, Jerod Denton*. -
Potential therapeutic benefit of exogenous ketone ester administration in delirium: a narrative review.
Ryan Smith*, Fiona Harrison, Julie Bastarache, Shawniqua Williams Roberson, Elma Zaganjor, Pratik Pandharipande, Todd Rice, Wes Ely.
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Department of Pharmacology |
Other basic biomedical papers |
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Clonal hematopoiesis of indeterminate potential influences breast cancer outcomes in a genotype-specific manner. Clinical Cancer Research.
Sarah Reed*, Chad Potts, Leo Luo, Riley Bergman, Justin Kemp, Ethan Fox, Bryce Thomas, Lauren Ha, Vani Arora, Justin Cartailler, Melinda Sanders, Violeta Sanchez, Paula Gonzalez-Ericsson, Sarah Croessmann, Paula Hurley, Alex Bick, P. Brent Ferrell, Ben Ho Park*.
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First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.
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Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter.
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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200 465 21st Avenue South
Nashville, TN 37240
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