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3i Initiative Weekly Updates
Welcome to the 3i Weekly Update, your source for 3i relevant news and events. Please send all items of interest to Nicole.Frank@hsc.utah.edu by the end of the day on Thursdays.
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4/2- 4/9- MONDAY, APRIL 5 – FRIDAY, APRIL 9, 2021 - 2nd Annual Symposium for Underserved, Rural, and Global Education
- MONDAY, APRIL 5, 2 - 3 PM - Rising Stars in Cell Biology Seminar Series - Dr. Nabora Reyes - Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung
- TUESDAY, APRIL 6, 2021- Undergraduate Research Symposium
- TUESDAY, APRIL 6, 2 -3 PM- The Department of Neurobiology Seminar Series - Dr. David Holtzman - Dissecting the role of ApoE, TREM2, and microglia in Alzheimer’s disease pathogenesis
- WEDNESDAY, APRIL 7, 2021, 12 – 1 PM - Department of Internal Medicine Research Seminar Series - Pulmonary - COVID Research
- WEDNESDAY, APRIL 7, 2021, 2 – 3PM - Dr. Robby Bowles - CRISPR Epigenome Modulation for Advanced Cell Engineering
- THURSDAY, APRIL 8, 2021, 8 – 9 AM - Pediatric Grand Rounds - Diagnosis and Management of Pediatric Functional FI Pain Disorders
- THURSDAY, APRIL 8, 2021, 9 – 10 AM - Medical Mycology Trainee Seminar Series - Jacob L. Steenwyck - “When two become one: the hybrid origin of pathogenic Aspergillus fungi." and Bertrand Nyuyonge - “A short tandem repeat assay for studying genetic variation in Madurella mycetomatis (MmySTR)."
- THURSDAY, APRIL 8, 2021, 10:45AM – 12PM - Dr. Brian Murphy - Toward antibiotic discovery from a bacterial colony: A primer for academia.
- THURSDAY, APRIL 8, 2021, 12 – 1PM - Department of Internal Medicine Grand Rounds - Dr. John Valentine - Inflammatory Bowel Disease: A Look to the Future
- FRIDAY, APRIL 9, 2021, 11:45 AM – 2PM - Biomedical Engineering Seminar - Dr. Linda Liau - Translational experimental therapeutics of cell-based immunotherapy for brain tumors and the characterization of biomarkers of response to immune-based therapies
- FRIDAY, APRIL 9, 2021, 12 – 1PM - NEXUS Dialogues on Disparities - Racial Societal Stressors and Population-Level Health Outcomes"
- MONDAY, APRIL 12, 2021, 4 – 5PM - Pharmaceutics & Pharmaceutical Chemistry Seminars - Dr. Moein Moghimi - The Complement System: Complement Propriety and Conspiracy in Nanomedicine
- TUESDAY, APRIL 13, 2021, 12 – 1PM - Research Professionals Grand Rounds - Dr. Michael Dean - How YOU Can Scare Your Investigator into Submission
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- Annual Symposium: Sex, Gender and Women’s Health Across the Lifespan - THURSDAY, MAY 13, 2021
- 3i Initiative Spring 2021 Symposium - FRIDAY, ARPIL 30, 2021, 8:00 AM -5:00 PM
- 2021 COVID-19 Symposium - FRIDAY, JUNE 4, 2021, 8:00 AM -5:00 PM
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- Call for applications: 3i Training Grant - We are pleased to announce that we are accepting applications from graduate students for the Immunology, Infectious Disease and Inflammation (3i) Training Grant (3iTG). The Training Grant will provide support for one year, with the potential to renew for a second year of support. We will be appointing 2 graduate student trainees this year. Some of the features of the training program include support for mentored research, a clinical immunology rotation at ARUP (pandemic permitting), training in data analysis and publishing, grant writing and career planning, mentored preparation and submission of F award proposal or equivalent, yearly presentation of data to the immunology community and partial support for travel to scientific meetings to present research findings. See application instructions here. Applications are due April 12th, 2021
- CCTS Peer Grant Review Program - Now Accepting Research Proposals for Pre-Submission Peer Review - The Utah Center for Clinical and Translational Science (CCTS) is now accepting research proposals for pre-submission peer review. The program accepts proposals from investigators conducting research at any point along the translational science spectrum aiming to improve the health of individuals and the public. Please limit one proposal submission per investigator to the PGR. NIH review criteria will be used to score each submission. Formal reviews will be returned to the investigator by May 3, 2021. Submission Requirements Investigators are required, via email, to submit a) the completed CCTS Peer Grant Review Face Page form (see below or fillable version); b) their NIH Biographical Sketch, Specific Aims, Research Strategy, and Bibliography & References Cited as word documents; and c) any other appropriate ancillary documents as a single PDF (see Guidance Checklists) to Breanne Johnson (Breanne.Johnson@hsc.utah.edu) no later than 4:00 pm on Thursday, April 23rd, 2021.
- Hatch Scholar for T1D Research - Request for Applications - due April 30, 2021 - We are pleased to announce the sixth annual Hatch Family Scholar Award Competition for graduate students and postdoctoral fellows at the University of Utah. The purpose of this award is to honor the Hatch family by rewarding a junior research scientist that is conducting research in the field of Type 1 Diabetes. A minimum prize of $1,000 will be awarded. Prizes are subject to federal tax regulations. Applications and all supporting documents should be compiled as one PDF and submitted electronically through the University of Utah’s Competition Space interface at http://utah.infoready4.com/ by April 30, 2021 at 5pm, search “The Paul Shurtleff Hatch and Heidi Hatch Ford Scholar Award for Type 1 Diabetes Research.” See attached RFA for more details.
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- Open Postdoctoral Research Position - Tumor Immunology - The Department of Internal Medicine, Division of Gastroenterology is seeking a highly motivated Postdoctoral Fellow to study novel immunotherapy approaches for gastrointestinal cancers. Experience with mouse work, flow cytometry, and immune cell assays is preferable. Applicants must have obtained a PhD in cancer biology, immunology, or a related field within the past three years. Strong oral and written English skills are required. The successful candidate should have independent research skills and a track record of success in the laboratory.
Interested applicants please submit a CV and contact information for 3 references to ellen.beswick@hsc.utah.edu
- Open Postdoctoral Research Position - The Puri Lab at the University of Utah seeks to hire a postdoctoral research associate to work on a funded project studying the biosynthesis of natural products made by underexplored bacteria. The ideal candidate will have a Ph.D. in Biochemistry, Chemistry, Microbiology, or a related field, and experience with protein expression, purification, and enzymology. Interested applicants should contact Aaron Puri directly (a.puri@utah.edu) with a cover letter, CV, and contact information for 3 references.
- SEAL (Science Excelerator and Leadership) Program Position Open - With this change in mind, the Gregg lab at the University of Utah is transitioning to a new model of science and discovery that caters to professional scientists by launching the SEAL (Science Excelerator and Leadership) Program. We are investigating new ways to take on higher impact scientific problems and make major advances in a shorter period of time. To help with this, the lab will transition to a new name – the Precision Brain Genetics Lab. This name change reflects the focus of the science and important roles of senior investigators in the lab and their capability to obtain independent grants if they wish. Right now, we are seeking to recruit a new SEAL program scientist to the lab at the level of a career track assistant professor, staff scientist or postdoctoral fellow.
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3i Funding Opportunities
Current Federal and Private FOAs applicable to the 3is can be found on the U's pivot page. New FOAs announced this week:
- Limited Submission Opportunities. Contact Lynn Wong, Director of Foundation Relations with any questions. Applications are submitted through InfoReady.
- RFA-RM-21-012 - Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases
- RFA-AR-21-015 - Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases: Disease Teams for Rheumatoid Arthritis, Lupus, Psoriatic Spectrum Diseases, and Sjögren’s Syndrome
- RFA-AI-21-012 - Understanding Post-Transcriptional Regulation of Intact and Defective HIV RNA
- RFA-AI-21-023 - Respond: Epidemiology to End the HIV Epidemic (RESPOND: EEE)
- RFA-AI-21-009 - Mechanisms of HIV Resistance to Broadly Neutralizing Antibodies (bNAbs)
- RFA-TW-21-001 - Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth) – Research
- RFA-FD-21-034 - AAV Vector manufacturing for diseases affecting very small populations
- RFA-RM-21-021 - Transformative Research to Address Health Disparities and Advance Health Equity
- RFA-AI-21-025 - Prevention Strategies to End the HIV Epidemic
- RFA-AI-21-024 - Multidisciplinary Treatment Approaches to End the HIV Epidemic
A monthly funding newsletter from PIVOT is sent to 3i investigators on the 2nd Monday of the month. If you have not been receiving the newsletter and would like to be added, please email Nicole.Frank@hsc.utah.edu.
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3i Investigator PublicationsCongratulations to the teams who published this week. If you have a publication that you would like included, please email us.
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A recent paper in this journal concerning parasites of rock pigeons (Columba livia) published by Ali and colleagues exemplifies a growing trend of misidentified parasites in the literature, despite increased online resources that should help facilitate accurate identification. In the Ali et al. paper, a pigeon louse in the genus Columbicola (Phthiraptera: Ischnocera) is misidentified as Menopon gallinae, which is a parasite of chickens (Gallus gallus) and their relatives; moreover, this louse is...
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Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular respiration, mitochondrial dynamics, and tubular epithelial cell (TEC) differentiation, while upregulation of FAO in kidney tubules provided protection from kidney fibrosis and functional decline.
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a reciprocal translocation [t(9;22)(q34;q11.2)] that leads to the fusion of ABL1 gene sequences (9q34) downstream of BCR gene sequences (22q11) and is cytogenetically visible as Philadelphia chromosome (Ph). The resulting BCR/ABL1 chimeric protein is a constitutively active tyrosine kinase that activates multiple signaling pathways, which collectively lead to malignant transformation. During the early (chronic) phase of...
Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of cardiometabolic diseases, including coronary artery disease, diabetes mellitus, cardiomyopathy and heart failure. These lifestyle factors, when combined with genetic predispositions, increase the levels of circulating lipids, which can accumulate in non-adipose tissues, including blood vessel walls and the heart. The metabolism of these lipids produces bioactive intermediates that disrupt cellular...
CONCLUSION: Our work connects MRP9 with bile duct homeostasis and cholestatic liver disease for the first time. It identifies a potential therapeutic target to attenuate bile acid-induced cholangiocyte injury.
CONCLUSIONS: ICIs were not cost-effective as neoadjuvant therapies, except when atezolizumab was compared with ddMVAC. Randomized clinical trials, larger sample sizes and longer follow-up are required to better understand the value of ICIs as neoadjuvant treatments.
CONCLUSION: In this real-world study of PsA therapies with differing mechanisms of action, the IL-12/23i demonstrated longer persistence and higher adherence than either TNFis or tsDMARDs, and comparability to IL-17is.
OBJECTIVES: Patient-generated health data (PGHD) are clinically relevant data captured by patients outside of the traditional care setting. Clinical use of PGHD has emerged as an essential issue. This study explored the evidence to determine the extent of and describe the characteristics of PGHD integration into electronic health records (EHRs).
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Some RIG-I-like receptors discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3'-overhanging termini. We investigated the transient kinetic mechanism of the dmDcr-2 reaction using a rapid reaction stopped-flow technique and time-resolved fluorescence spectroscopy. Indeed, we found that ATP binding to dmDcr-2's helicase domain impacts association and dissociation kinetics of dsRNA in a...
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