The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
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Department of Biochemistry |
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A reversible feedback mechanism regulating mitochondrial heme synthesis. Journal of Biological Chemistry.
Iva Chitrakar*, Alexis Roberson, Pedro Ayres-Galhardo, Breann Brown*.
Center for Structural Biology: Heme biosynthesis is controlled by reversible feedback mechanism inside the mitochondrial matrix -
High-throughput screening identifies a trafficking corrector for long-QT syndrome-associated KCNQ1 variants. JCI Insight.
Katherine Clowes Moster*, Ana Chang-Gonzalez, Ian Romaine, Katherine Stefanski, Mason Wilkinson, Joshua Bauer, Thomas Hasaka, Emily Days, Kathryn Butcher, Gary Sulikowski, Alex Waterson, Jens Meiler, Kaitlyn Ledwitch, Charles Sanders*.
Supported by the Cell and Developmental Biology Equipment Resource, the High-Throughput Screening Facility, and the Molecular Design and Synthesis Center.
SBGrid Community News: Promising small molecule may help with sudden cardiac death -
Discovery of Spiro[chromane-2,4'-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV-2 Papain-like Protease. Journal of Medicinal Chemistry.
Qiangqiang Wei*, Ashley Taylor, Nagaraju Miriyala, Mahesh Barmade, Zachary Gentry, Jordan Anderson-Daniels, Kevin Teuscher, Mackenzie Crow, Chideraa Apakama, Taylor South, Tyson Rietz, Kangsa Amporndanai, Jason Phan, John Sensintaffar, Mark Denison, Taekyu Lee, Stephen Fesik*.
Supported by the High-Throughput Screening Facility. -
The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair. Nucleic Acids Research.
Mihyun Kim* (Institute for Basic Science), Areetha D’Souza, Walter Chazin.
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Department of Cell and Developmental Biology |
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ER remodelling is a feature of ageing and depends on ER-phagy. Nature Cell Biology.
Eric Donahue*, Nathaniel Hepowit, Elizabeth Ruark, Alexandra Mulligan, Brennen Keuchel, Li Peng, Stedman Stephens, Derek Johnson, Natalie Wallace, Lauren Jackson, Rafael Arrojo e Drigo, Andrew Folkmann, Jason MacGurn, Kristopher Burkewitz*.
Supported by the Cell Imaging Shared Resource.
School of Medicine Basic Sciences: Aging researchers find new puzzle piece in the game of longevity -
Non-Muscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling. Circulation Research.
James Hayes*, Dharmendra Choudhary, Dylan Ritter, Abigail Neininger-Castro, Alaina Willet, Leah Caplan, Yu Wang, Xiao Liu, Nilay Taneja, Zachary Sanchez, Kyra Smart, David Armstrong, Cynthia Reinhart-King, Qi Liu, Matthew Tyska, W. David Merryman, Quinn Wells, Ela Knapik, Dylan Burnette*.
Supported by the Cell Imaging Shared Resource.
Labeled by the journal as a “Featured Article.” Also featured on the cover of the journal.
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Department of Molecular Physiology and Biophysics |
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Improved polygenic risk prediction models for breast cancer subtypes in women of African ancestry. Nature Genetics.
James Li* (University of Chicago), Guochong Jia, Tuya Pal, Xiao-Ou Shu, Jirong Long, Sonya Reid, Qiuyin Cai, Jie Ping, Ran Tao, Bingshan Li, Xingyi Guo, Wei Zheng.
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Department of Pharmacology |
- Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy. Neuroscience.
Sheryl Anne Vermudez*, Geanne Freitas, Colleen Niswender*. -
Spatial transcriptomics reveals organizational properties of mouse spinal cord and alterations in neuropathic pain (preprint). bioRxiv.
Qimeng Wang*, Yunfei Hu, Yuling Zhu, Gautham Chelliah, Melissa Sobanko, Xin Maizie Zhou, Shan Meltzer*. - The expanding roles of adhesion GPCRs in neural circuit assembly. Molecules and Cells.
Shane Watson*, Richard Sando*. -
Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2. Journal of Medicinal Chemistry.
Daniel Haymer*, Renn Duncan, Alice Rodriguez, Allie Han, Richard Lindsay, , N. Kithmini Wijesiri, Analisa Thompson Gray, Srinivasan Krishnan, Aidong Qi, Benjamin Brown, Olivier Boutaud, Darren Engers, Carrie Jones, Colleen Niswender*, Craig Lindsley*, Aaron Bender*. -
Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers. Alzheimer’s & Dementia.
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Reciprocal regulation of the H3 histamine receptor in Rett syndrome and MECP2 Duplication syndrome: implications for therapeutic development (preprint). bioRxiv.
Kelly Weiss*, Sheryl Anne Vermudez, Geanne Freitas, Shalini Dogra, Mac Meadows, Rocco Gogliotti, Colleen Niswender*. -
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2. Journal of Chemical Information and Modeling.
Oleksandra Herasymenko* (University Health Network), Jens Meiler. -
Glycan masking in immunogen design: computational and experimental methods. Frontiers in Immunology.
Gustavo Araiza*, Josuel Morel*, Minh Tran, Shan Jiang, Emika Miyamoto, Kyle Brown, Jens Meiler, Cristina Martina*.
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Other Vanderbilt basic biomedical research |
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The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children. The Journal of Infectious Diseases.
Maribeth Nicholson*, Siyuan Ma, Britton Strickland, Mia Cecala, Lisa Zhang, Seth Reasoner, Matthew Munneke, Meghan Shilts, Eric Skaar, Suman Das*.
Featured as an “Editor’s choice” paper by the journal.
VUMC News: Gut microbiome differs according to C. diff symptom status -
Modeling the Impact of Protein Mutations on Chemical Reactions for Biochemistry, Protein Engineering, and Drug Discovery. Journal of Chemical Theory and Computation.
Zhongyue John Yang*.
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First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.
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Faculty resource: Proofig AI
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Proofig AI is your go-to platform for catching image issues like duplications, manipulations, plagiarism, and AI-generated problems. This resource is provided at no cost to primary SOMBS faculty and is part of our commitment to supporting research excellence and maintaining the highest standards of scientific integrity. Faculty can access Proofig by visiting its homepage or their OneVU dashboard.
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Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter. Please send the paper’s URL.
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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200, 465 21st Avenue South
Nashville, TN 37240
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