MyMP- June 2016
MyMP- June 2016
June 7, 2016
MyMP-June  2016
A monthly eBulletin
PMI seminar series- Mondays, room 214 Light Hall, 12:00pm
  • PMI seminar Calendar
  • MPHI Journal Club
    days vary - A4224 MCN, 4:00-5:00pm:


  • RIP(Research in Progress)
    Thursdays C2303 MCN, 9:30-10:30am:
  • Research in Progress Calendar

  • Rheumatology seminar series
    Thursdays-U1202 MRB III
    1st Floor Brain Institute Conference Room
    11:30 AM – 12:30 PM
  • Rheumatology Calendar
  • https://app.e2ma.net/app2/campaigns/create/209072908/#https://app.e2ma.net/app2/campaigns/create/210448927/#
    Infectious Disease Grand Rounds
    12:00 noon – 1:00 PM Thursday Afternoons
    A-2200 MCN 12:00 - 1:00 pm

    Pediatric Infectious Diseases Research Conference
  • Peds ID Calendar 2015-16
  • Immunology Journal Club
    Fridays A4224 MCN, 12:00-1:00pm:
  • Immunology Journal Club Calendar
  • Work in Progress(WIP)
    Tuesdays,9:00am-10:00am, Room C2303 MCN


    A note from your local DGS
    Dr. Jerome and the program in Cellular and Molecular Pathology extend a warm welcome to Erin Fey, who has joined the lab of Dr. Tom Stricker. 
    Erin, we look forward to celebrating your accomplishments!

    Division Announcements
    - June 10 - MP 2nd Friday Happy Hour.  Tim Cover and Maria Hadjifrangiskou labs will be hosting.
    - June 24 - 4:00 pm, A5305 MCN, Special Departmental Happy Hour -  Funded by the award received at the Annual Postdoc Symposium.  PMI postdocs will be supplying plenty of food and both alcoholic and non-alcoholic beverages.   Everyone is welcome to come, so please feel free to invite your mentors and co-workers to attend.  If you plan on having an alcoholic beverage, please bring your ID with you.  
    - June 28 - MP Division faculty meeting- 3:00pm, room A5305 MCN - Chalk-talk, Chris Aiken,Ph.D.
    - A total of 41 publications featuring commentaries, reviews and primary research have posted on NCBI from faculty in our division since last month's myMP. We selected the publication with the highest number of labs collaborating for today's feature. The work by Varga et al. is featured below.
    If you would like to contribute an article highlight, from your lab or the lab of a colleague within MP, please feel free to email us.
    Our Publications - May
    • 12. IgA nephropathy. Lai KN, Tang SC, Schena FP, Novak J, Tomino Y, Fogo AB,Glassock RJ.
      Nat Rev Dis Primers. 2016 Feb 11;2:16001. doi: 10.1038/nrdp.2016.1.
    • 26. Impact of pre-adapted HIV transmission. Carlson JM, Du VY, Pfeifer N, Bansal A, Tan VY, Power K, Brumme CJ, Kreimer A, DeZiel CE, Fusi N, Schaefer M, Brockman MA, Gilmour J, Price MA, Kilembe W, Haubrich R, John M, Mallal S,Shapiro R, Frater J, Harrigan PR, Ndung'u T, Allen S, Heckerman D, Sidney J, Allen TM, Goulder PJ, Brumme ZL, Hunter E, Goepfert PA.
      Nat Med. 2016 May 16. doi: 10.1038/nm.4100. [Epub ahead of print]
    • 33. Answers to Epilogue questions. Maalouf FI, Coggins SA, Phillips JA 3rd,Stefanescu BM, Weitkamp JH.
      Arch Dis Child Educ Pract Ed. 2016 Jun;101(3):168. doi: 10.1136/archdischild-2015-308719a. No abstract available.
    Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system
    Varga et al.
    Oncogene 2016 May 9. doi: 10.1038/onc.2016.158. [Epub ahead of print]
    • Helicobacter pylori utilizes the cag type IV secretion system (T4SS) to inject the bacterial oncoprotein CagA and fragments of peptidoglycan into host gastric epithelial cells. In this study, Varga et al. demonstrate that:
    •  H. pylori activates TLR9 in a cag T4SS-depenedent manner
    • H. pylori-mediated TLR9 activation and TLR9 expression are directly related to gastric cancer risk in human populations
    • Microbial DNA is translocated into host cells via cag T4SS activity
    • cag T4SS-depenednet transfer of bacterial DNA is both protected as well as exposed to the extracellular space during transport to host cells
    • This study indicates that TLR9 activation via cag T4SS activity may modify the risk for gastric malignancy within the context of H. pylori infection

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