Work in Progress(WIP)
Tuesdays,9:00am-10:00am, Room C2303 MCN
A note from your local DGS
Dr. Jerome and the program in Cellular and Molecular Pathology extend a warm welcome to Erin Fey, who has joined the lab of Dr. Tom Stricker.
Erin, we look forward to celebrating your accomplishments!
Division Announcements
- June 10 - MP 2nd Friday Happy Hour. Tim Cover and Maria Hadjifrangiskou labs will be hosting.
- June 24 - 4:00 pm, A5305 MCN, Special Departmental Happy Hour - Funded by the award received at the Annual Postdoc Symposium. PMI postdocs will be supplying plenty of food and both alcoholic and non-alcoholic beverages. Everyone is welcome to come, so please feel free to invite your mentors and co-workers to attend. If you plan on having an alcoholic beverage, please bring your ID with you.
- June 28 - MP Division faculty meeting- 3:00pm, room A5305 MCN - Chalk-talk, Chris Aiken,Ph.D.
- A total of 41 publications featuring commentaries, reviews and primary research have posted on NCBI from faculty in our division since last month's myMP. We selected the publication with the highest number of labs collaborating for today's feature. The work by Varga et al. is featured below.
If you would like to contribute an article highlight, from your lab or the lab of a colleague within MP, please feel free to email us.
26. Impact of pre-adapted HIV transmission. Carlson JM, Du VY, Pfeifer N, Bansal A, Tan VY, Power K, Brumme CJ, Kreimer A, DeZiel CE, Fusi N, Schaefer M, Brockman MA, Gilmour J, Price MA, Kilembe W, Haubrich R, John M, Mallal S,Shapiro R, Frater J, Harrigan PR, Ndung'u T, Allen S, Heckerman D, Sidney J, Allen TM, Goulder PJ, Brumme ZL, Hunter E, Goepfert PA. Nat Med. 2016 May 16. doi: 10.1038/nm.4100. [Epub ahead of print]
Pathogenic Helicobacterpylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system
Varga et al.
Oncogene 2016 May 9. doi: 10.1038/onc.2016.158. [Epub ahead of print]
Helicobacter pylori utilizes the cag type IV secretion system (T4SS) to inject the bacterial oncoprotein CagA and fragments of peptidoglycan into host gastric epithelial cells. In this study, Varga et al. demonstrate that:
H. pylori activates TLR9 in a cag T4SS-depenedent manner
H. pylori-mediated TLR9 activation and TLR9 expression are directly related to gastric cancer risk in human populations
Microbial DNA is translocated into host cells via cag T4SS activity
cag T4SS-depenednet transfer of bacterial DNA is both protected as well as exposed to the extracellular space during transport to host cells
This study indicates that TLR9 activation via cag T4SS activity may modify the risk for gastric malignancy within the context of H. pylori infection