Recently published

• Cannabidiol Differentially Modulates Synaptic Release and Cellular Excitability in Amygdala Subnuclei. ACS Chemical Neuroscience.
  Nathan Winters, Veronika Kondev, Brad Grueter.
  
  “We found that CBD had robust effects on the synaptic properties and excitability of amygdala neurons,” Nathan Winters.
  
  
• Advances in Mapping Tumor Progression from Precancer Atlases. Cancer Prevention Research. 
  Zhengyi Chen, Ken Lau.
  
  "Review by graduate student [Lucy Zhengyi Chen] discussing the timing and effects of genomic alterations and microenvironmental changes across different pre-cancer types,” Ken Lau lab.
  
  
• SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. The Journal of Clinical Investigation.
  Jennifer Pilat, Rachel Brown, Zhengyi Chen, Nathaniel Berle, Adrian Othon, M. Washington, Shruti Anant, Victoria Ng, Joshua Thompson, Justin Jacobse, Jeremy Goettel, Ethan Lee, Yash Choksi, Ken Lau, Sarah Short, Christopher Williams.
  
  
• Targeting what is not there to treat cancer. BioEssays.
  William Tansey
  
  
• Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis. Metabolism.
  Mari Vázquez-Borrego (University of Illinois at Chicago), Mercedes del Río-Moreno (UIC), Owen McGuinness.
  
  
• Electrophilic reactive aldehydes as a therapeutic target in colorectal cancer prevention and treatment. Oncogene.
  Alain Gobert, Mohammad Asim, Thaddeus Smith, Kamery Williams, Daniel Barry, Margaret Allaman, Kara McNamara, Caroline Hawkins, Alberto Delgado, Shilin Zhao, Blanca Piazuelo, Kay Washington, Lori Coburn, Keith Wilson.
  
  “Work from Dr. Keith Wilson’s lab shows that a natural compound derived from buckwheat seeds called 2-hydroxybenzylamine reduces tumorigenesis in models of colitis-associated carcinogenesis and of sporadic colorectal cancer,” VUMC Molecular Pathogenesis.
  
  
• A Comprehensive Approach to Sample Preparation for Electron Microscopy and the Assessment of Mitochondrial Morphology in Tissue and Cultured Cells. Advanced Biology.
  Antentor Hinton Jr., Kit Neikirk, Bryanna Shao, Zer Vue, Larry Vang, Heather Beasley, Andrea Marshall, Dominique Stephens, Steven Damo.
  
  “Check out our recent publication by [Antentor Hinton Jr.] out in [Advanced Biology] setting the standard for sample preparation for advanced 3D [electron microscopy] to show [mitochondria],” Dale Abel.
  
  
• CLASPs stabilize the pre-catastrophe intermediate state between microtubule growth and shrinkage. Journal of Cell Biology.
  Elizabeth Lawrence, Saptarshi Chatterjee, Marija Žanić.
  
  “[Beth Lawrence] & [the Marija Žanić lab] show that CLASPs regulate microtubule dynamics by stabilizing a metastable intermediate state of the microtubule end between growth & shrinkage,” Journal of Cell Biology.
  
  
• An immunosuppressed microenvironment distinguishes lateral ventricle-contacting glioblastomas. JCI Insight.
  Todd Bartkowiak, Sierra Lima, Madeline Hayes, Akshitkumar Mistry, Asa Brockman, Justine Sinnaeve, Nalin Leelatian, Caroline Roe, Bret Mobley, Silky Chotai, Kyle Weaver, Reid Thompson, Lola Chambless, Rebecca Ihrie, Jonathan Irish.
  
  
• The Role of Mobile Genetic Elements in Virulence Factor Carriage from Symptomatic and Asymptomatic Cases of Escherichia coli Bacteriuria. Microbiology Spectrum.
  Grace Morales, Benjamin Abelson, Seth Reasoner, Jordan Miller, Maria Hadjifrangiskou, Jonathan Schmitz.
  
  “Here, we wanted to characterize MGE from a diverse cohort of E. coli strains from patients who presented with a positive urine culture,” Grace Morales.
  

Highlighted across the web

• RAD51 bypasses the CMG helicase to promote replication fork reversal. Science.
  Wenpeng Liu, Rahul Bhowmick, David Cortez.
  
  Highlighted on Vanderbilt's Research News page.
  

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