Recently published

• Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue. Advanced Biology.
  Amber Crabtree, Kit Neikirk, Andrea Marshall, Larry Vang, Aaron Whiteside, Qiana Williams, Christopher Altamura, Trinity Celeste Owens, Dominique Stephens, Bryanna Shao, Alice Koh, Mason Killion, Jade Stanley, Danielle Dean, Ho-Jin Koh, Jennifer Gaddy, Jamaine Davis, Elma Zaganjor, Steven Damo, Zer Vue, Antentor Hinton Jr.
  
  
• Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons. Proceedings of the National Academy of Sciences.
  Veronika Kondev, Mustafa Najeed, Niharika Loomba, Jordan Brown, Danny Winder, Brad Grueter.
  
  “New paper from students [Veronika Kondev], [Niharika Loomba] and collaborators from [Danny Winder] and [Brad Grueter] labs showing synaptic and cellular Endocannabinoid mechanisms sculpt stress-induced adaptations in NAc SOM+ neuron associated circuits,” Sachin Patel.
  
  
• Development of a selective and high affinity radioligand, [3H]VU6013720, for the M4 muscarinic receptor. Molecular Pharmacology.
  Aidong Qi, Haley Kling, Natasha Billard, Alice Rodriguez, Li Peng, Jonathan Dickerson, Julie Engers, Aaron Bender, Craig Lindsley, Jerri Rook, Colleen Niswender.
  
  
• Temporal modelling of the biofilm lifecycle (TMBL) establishes kinetic analysis of plate-based bacterial biofilm dynamics. Journal of Microbiological Methods.
  Kyle Enriquez, Dale Plummer, Preston Neufer, Walter Chazin, William Dupont, Eric Skaar.
  
  

• Prostaglandin I2 Therapy Promotes Treg Generation in Patients with Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine.
  Allison Norlander, Masako Abney, Jacqueline-Yvonne Cephus, Caroline Roe, Jonathan Irish, Nicholas Shelburne, Dawn Newcomb, Anna Hemnes, Stokes Peebles Jr.
  
  "A recent article co-authored by [Jonathan Irish] & [Dawn Newcomb] shows data that supports the use of Prostaglandin I2 analogs as [anti-inflammatory] therapeutics that promote Treg function in humans,” VUMC Molecular Pathogenesis.
  
  
• Spatially Resolved Proteomics Reveals Lens Suture-Related Cell–Cell Junctional Protein Distributions. Investigative Ophthalmology & Visual Science.
  Zhen Wang, Romell Gletten, Kevin Schey.
  
  
• Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity. JCI Insight.
  Jeeyeon Cha, Xin Tong, Emily Walker, Anna Osipovich, Min Guo, Jin-hua Liu, Zachary Loyd, Mark Magnuson, Roland Stein.
  
  
• Hallmarks of CD8+T cell dysfunction are established within hours of tumor antigen encounter before cell division. Nature Immunology.
  Michael Rudloff, Natalie Favret, Jessica Roetman, Carlos Detrés Román, Megan Erwin, Kristen Murray, Sriya Jonnakuti, Mary Philip.
  
  “Dysfunction can occur just hours after activation and coincides with large scale chromatin remodeling prior to cell division,” Michael Rudloff.
  
  
• Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor. Proceedings of the National Academy of Sciences.
  Dianxin Liu, Ryan Ceddia, Wei Zhang, Fubiao Shi, Sheila Collins.
  
  
• Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity. The Journal of Clinical Investigation.
  Ryan Ceddia, Zack Zurawski, Analisa Thompson Gray, Feyisayo Adegboye, Fubiao Shi, Dianxin Liu, Jose Maldonado, Simon Alford, Julio Ayala, Owen McGuinness, Sheila Collins, Heidi Hamm.
  
  
• Sam50 is Associated with Fragmentation and Alterations in Metabolism in Human and Murine Myotubes. Microscopy & Microanalysis. 
  Andrea Marshall, Edgar Garza-Lopez, Zer Vue, Larry Vang, Antentor Hinton Jr.
  
  
• Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging. Microscopy & Microanalysis. 
  Antentor Hinton Jr., Zer Vue, Andrea Marshall.
  
  
• Decrease in Mouse Skeletal Muscle During Aging is Due to Altered Mitochondrial Networks and the MICOS Complex. Microscopy & Microanalysis.
  Zer Vue, Edgar Garza-Lopez, Kit Neikirk, Larry Vang, Antentor Hinton Jr.
  
  
• Deletion of complement factor 5 amplifies glucose intolerance in obese male but not female mice. Endocrinology and Metabolism.
  Nathan Winn, Joslin Blair, Alec Rodriguez, Jamie Garci, Tzushan Yan, Alyssa Hasty.
  
  
• Towards the Visual Proteomics of C. reinhardtii using High-throughput Collaborative in situ Cryo-ET. Microscopy and Microanalysis.
  Sagar Khavnekar (Max Planck Institute of Biochemistry), William Wan.
  
  
• Studying the Molecular Mechanisms of Ebola Virus with in situ Structural Biology. Microscopy & Microanalysis. 
  William Wan.
  
  
• Elucidating the Mechanism of Phosphatidylserine Exposure During Ebola Virus Assembly. Microscopy & Microanalysis.
  Tyler Huth, William Wan.
  
  
• TOMOMAN: Streamlining Cryo-electron Tomography and Subtomogram Averaging Workflows Using TOMOgram MANager. Microscopy & Microanalysis.
  Sagar Khavnekar, William Wan.
  

Preprints

• Modeling membrane geometries implicitly in Rosetta. bioRxiv.
  Hope Woods, Jens Meiler.
  
  “In membrane protein structural biology, one draw back of implicit membrane modeling is stagnant geometry (e.g. flat membranes only).. until now! Check out this preprint from Hope in the [Jens Meiler lab] on modeling alternative membrane geometries w/ Rosetta,” Eli Fritz McDonald.
  
  
• Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection. bioRxiv.
  Luisella Spiga, Ryan Fansler, Yasiru Perera, Nicolas Shealy, Matthe Munneke, Teresa Torres, Holly David, Xinchun Ran, Katrina Richardson, Zhongyue Yang, Eric Skaar, Mariana Byndloss, Walter Chazin.
  
  “A recent preprint coauthored by [Eric Skaar], Mariana Byndloss] & [Wenhan Zhu] shows that B. thetaiotaomicron secretes a lipoprotein onto the cell surface and into the extracellular milieu to acquire xenosiderophores,” VUMC Molecular Pathogenesis.
  
  

Highlighted across the web

• Bioinformatics Screen Reveals Gli-Mediated Hedgehog Signaling as an Associated Pathway to Poor Immune Infiltration of Dedifferentiated Liposarcoma. Cancers.
  Erik Beadle, Natalie Bennett, Julie Rhoades.
  
  Highlighted in the VUMC Reporter.
  
  
• Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division. Nature Immunology.
  Michael Rudloff, Natalie Favret, Jessica Roetman, Carlos Detrés Román, Megan Erwin, Kristen Murray, Sriya Jonnakuti, Mary Philip.
  
  Highlighted by Accelerating Cancer Immunotherapy Research.
  
  “CD8+ T cell dysfunction is induced within 6 hours after the first encounter with antigens in tumors – before the first round of cell division even occurs,” ACIR.
  
  
• Activation of thousands of genes in the lungs and kidneys by sepsis is countered by the selective nuclear blockade. Frontiers in Immunology.
  Huan Qiao, Jozef Zienkiewicz, Yan Liu, Jacek Hawiger.
  
  Highlighted in the VUMC Reporter.
  

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