Recently published

• Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis. Journal of Biological Chemistry.
  Abhijit Shinde, Elizabeth Nunn, Genesis Wilson, Mathew Chvasta, Julia Pinette, Jacob Myers, Sun Peck, Elma Zaganjor.
  
  
• Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. Nature Communications.
  Danyang Zhang (MRC Laboratory of Molecular Biology), Terunaga Nakagawa.
  
  
• Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS. Bioorganic & Medicinal Chemistry Letters.
  Cayden Dodd, Keagan Chronister, Upendra Rathnayake, Lauren Parr, Kangjun Li, Sichen Chang, Dehui Mi, Emily Days, Joshua Bauer, Hyekyung Cho, Olivier Boutaud, Jerod Denton, Craig Lindsley, Changho Han.
  
  
• Pavlovian-conditioned opioid tolerance. Science Advances.
  Zahra Farahbakhsh, Cody Siciliano
  
  
• Revisiting focused ion beam scanning electron microscopy. Trends in Biochemical Sciences.
  Andrea Marshall, Antentor Hinton Jr.
  
  
• β2ARs: double edge sword in heart function. Trends in Molecular Medicine.
  Heather Beasley, Celestine Wanjalla, Annet Kirabo, Antentor Hinton Jr.
  
  
• Tissue-specific heteroplasmy segregation is accompanied by a sharp mtDNA decline in Caenorhabditis elegans soma. iScience.
  Nikita Tsyba, Gaomin Feng, Lantana Grub, James Held, Adrianna Strozak, Kristopher Burkewitz, Maulik Patel.
  
  
• Extracellular vesicles and nanoparticles: emerging complexities. Trends in Cell Biology.
  Dennis Jeppesen, Qin Zhang, Jeffrey Franklin, Robert Coffey.
  
  
• Comprehensive isolation of extracellular vesicles and nanoparticles. Nature Protocols.
  Qin Zhang, Dennis Jeppesen, James Higginbotham, Jeffrey Franklin, Robert Coffey.
  
  
• Cell and gene therapy for kidney disease. Nature Reviews Nephrology.
  Jennifer Peek, Matthew Wilson.
  
  
• Structured tracking of alcohol reinforcement (STAR) for basic and translational alcohol research. Molecular Psychiatry.
  Alex Brown, Hannah Branthwaite, Zahra Farahbakhsh, Snigdha Mukerjee, Patrick Melugin, Keaton Song, Cody Siciliano.
  
   “These findings point towards potential biomarkers that may explain some variance in drinking behaviors across animals,” Alex Brown.
  
  
• Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension. Journals of the American College of Cardiology.
  Matthew Alexander, Bethany Dale, Charles Smar, Fernando Elijovich, Cara Wogsland, Sierra Lima, Jonathan Iris, Meena Madhur.
  
  “Taken together, these results provide novel evidence for decreases in anti-inflammatory and/or hypofunctional T-cell populations that may contribute to the enhanced inflammation in human hypertension,” Matt Alexander.
  
  
• The in vivo measurement of replication fork velocity and pausing by lag-time analysis. Nature Communications.
  Dean Huang (University of Washington), Anna Johnson, Houra Merrikh.
  
  “This collaborative work with Paul Wiggins puts forth a method for locus-specific measurements of fork velocity, in units of kilobases per second, as well as replisome pause durations,” Houra Merrikh.
  

Preprints

• A role for N6-methyldeoxyadenosine in C. elegans mitochondrial genome regulation. bioRxiv.
  Lantana Grub, James Held, Tyler Hansen, Samantha Schaffner, Marleigh Canter, Evi Malagise, Maulik Patel.
  
  Excited to share our recent preprint from the Patel lab in which we identify that the mitochondrial genome of C. elegans is 6mA methylated,” James Held.
  

Tell us *before* your paper is published