Recently published

• The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue. Cell Reports.
  Neil Sprenkle, Nathan Winn, Kaitlyn Bunn, Yang Zhao, Deborah Park, Brenna Giese, John Karijolich, Henrique Serezani, Alyssa Hasty, Heather Pua.
  
  “…control of proliferation of a protective subset of LAMs by noncoding [RNAs] contributes to protection against diet-induced [obesity] metabolic dysfunction,”VUMC Molecular Pathogenesis.
  
  
• Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology.
  Brenna Appleton, Sydney Palmer, Harrison Smith, Lilly Stephens, Amy Major.
  
  “OxPAPC interferes with the differentiation and function of Tregs, suggesting oxidized phospholipids may be drivers of Treg dysregulation in atherosclerosis,”ATVB: An AHA Journal.
  
  
  
• Polarity kinases that phosphorylate F-BAR protein Cdc15 have unique localization patterns during cytokinesis and contributions to preventing tip septation in Schizosaccharomyces pombe. microPublication Biology.
  Maya Igarashi, Rahul Bhattacharjee, Alaina Willet, Kathleen Gould.
  
  
• Maintenance of heme homeostasis in Staphylococcus aureus through post-translational regulation of glutamyl-tRNA reductase. Journal of Bacteriology.
  Catherine Leasure, Jacob Choby, Eric Skaar.
  
  
• No Time to Relax and Unwind: Exploration of Topoisomerases and a Growing Field of Study. International Journal of Molecular Sciences.
  Joseph Deweese, Neil Osheroff.
  
  
• Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry. Biochemistry.
  Pradeep Pallan, Terry Lybrand, Martin Egli.
  
  
• Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation. Cell Reports.
  Veronika Kondev, Mustafa Najeed, Niharika Loomba, Danielle Adank, Eric Delpire, Danny Winder, Brad Grueter.
  
  
• Food restriction level and reinforcement schedule differentially influence behavior during acquisition and devaluation procedures in mice. eNeuro.
  Maxime Chevée, Courtney Kim, Nevin Crow, Emma Follman, Michael Leonard, Erin Calipari.
  
  
• MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer. Nature Communications.
  Zinab Doha (Oregon Health & Science University), Xiaoyan Wang (OHSU), Jennifer Pietenpol, Melinda Sanders.
  
  
• Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics. Journal of Biological Chemistry.
  Minsoo Kim, Eli McDonald, Carleen Sabusap, Bibek Timalsina, Lars Plate.
  
  “We showed attenuating translation sensitizes P67L to respond to VX-445 correction. This implies a previously unknown role for co-translational folding in VX-445 response,”Eli McDonald.
  
  
• Molecular signature incorporating the immune microenvironment enhances thyroid cancer outcome prediction. Cell Genomics.
  George Xu, Matthew Loberg, Jean-Nicolas Gallant, Quanhu Sheng, Sheau-Chiann Chen, Brian Lehmann, Megan Tigue, Courtney Phifer, Li Wang, Mario Saab-Chalhoub, Lauren Dehan, Qiang Wei, Rui Chen, Bingshan Li, Christine Kim, Donna Ferguson, James Netterville, Sarah Rohde, Carmen Solórzano, Lindsay Bischoff, Naira Baregamian, Aaron Shaver, Mitra Mehrad, Kim Ely, Daniel Byrne, Thomas Stricker, Barbara Murphy, Jennifer Choe, Fei Ye, Ethan Lee, Vivian Weiss.
  
  “We performed bulk RNA sequencing and whole exome DNA sequencing on a large cohort of thyroid tumors from VUMC and UW … to generate a molecular aggression and prediction (MAP) score that may enhance outcome prediction and response to immunotherapy," Vivian Weiss.
  

Editorials

• α2δ-1 as a New Target for Immunosuppressant-Induced Hypertension. Circulation Research.
  Antentor Hinton Jr., Annet Kirabo.

Preprints

• Rosetta Energy Analysis of AlphaFold2 models: Point Mutations and Conformational Ensembles. bioRxiv.
  Richard Stein, Hassane Mchaourab.

Highlighted across the web

In the media

• "Why Juneteenth matters for science." Nature Career Column.
  Antentor Hinton Jr.
  
  
• "Criticism builds against Ph.D. careers firm Cheeky Scientist." Science Careers.
  Kim Petrie was quoted.
  

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