Recently published

• SNAP25 differentially contributes to Gi/o-coupled receptor function at glutamatergic synapses in the nucleus accumbens. Frontiers in Cellular Neuroscience.
  Kevin Manz, José Zepeda, Zack Zurawski, Heidi Hamm, Brad Grueter.
  
  “Our work [demonstrates] direct action by G-proteins at the SNARE complex at select Gi/o-GPCR systems within the Nucleus Accumbens,” José Carlos Zepeda.
  
  
• A mathematical model of calcium signals around laser-induced epithelial wounds. Molecular Biology of the Cell.
  Aaron Stevens, James O’Connor, Andrew Pumford, Andrea Page-McCaw, Shane Hutson.
  
  
• Cardiovascular hemodynamics in mice with tumor necrosis factor receptor—associated factor 2 mediated cytoprotection in the heart. Frontiers In Cardiovascular Medicine.
  Andrea Marshall, Kit Neikirk, Zer Vue, Heather Beasley, Larry Vang, Taylor Barongan, Zoe Evans, Amber Crabtree, Elsie Spencer, Josephs Anudokem Jr, Remi Parker, Jamaine Davis, Dominique Stephens, Steven Damo, Antentor Hinton Jr.
  
  
• ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes. PLOS Genetics.
  Anna Osipovich, Karrie Dudek, Linh Trinh, Lily Kim, Shristi Shrestha, Jean-Philippe Cartailler, Mark Magnuson.
  
  
• Sampling the rainbow. Nature Chemical Biology.
  Maria Hadjifrangiskou.
  
  “A recent publication from [Maria Hadjifrangiskou] describes a new approach called RainbowSeq that enables transcriptional profiling in [biofilms] with increased spatial resolution,” VUMC Molecular Pathogenesis.
  
  
• Molecular basis of ligand-dependent Nurr1-RXRα activation. eLife.
  Xiaoyu Yu, Douglas Kojetin.
  
  “New findings from [Doug Kojetin] & collaborators … provide a molecular blueprint for ligand activation of Nurr1 transcription via small molecule targeting of Nurr1-RXRα,” Center for Structural Biology.
  
  
• It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease. Gut.
  Amelia Cephas, Kathleen DelGiorno.
  
  
• The fission yeast cytokinetic ring component Fic1 promotes septum formation. Biology Open.
  Anthony Rossi, Adam Bohnert, Kathleen Gould.
  
  “Grad student Tony Rossi’s … work started with an interesting genetic interaction between fic1 and myosin-II - which [led] to trying to determine if the budding yeast ingression progression complex also exists in pombe!” Gould lab.
  

Preprints

• Ribosomal Frameshifting Selectively Modulates the Biosynthesis, Assembly, and Function of a Misfolded CFTR Variant. bioRxiv.
  Patrick Carmody (Indiana University Bloomington), Madeline Herwig, Minsoo Kim, Eli McDonald, Lars Plate.
  
  “In our new preprint with the Schlebach Lab (IU), we show silent ribosomal frameshifting mutations 1) fail to change expression but 2) unexpectedly alter proteostasis and 3) strangely increase gating/function of F508del CFTR,” Eli Fritz McDonald.
  
  
• High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology. bioRxiv.
  Ayesha Muhammad, Maria Calandranis, Bian Li, Tao Yang, Daniel Blackwell, Lorena Harvey, Jeremy Smith, Ashli Chew, Dan Roden.
  
  “We [measured] cell surface trafficking and function of 2,500 variants in the potassium channel gene KCNE1,” Andrew Glazer.
  
  
• Mitotic spindle positioning protein (MISP) is an actin bundler that senses ADP-actin and binds near the pointed ends of filaments. bioRxiv.
  Angelo Morales, Matthew Tyska.
  
  “TIRF microscopy assays revealed that the microvillus actin bundler MISP loves … the pointed ends,” Matt Tyska.
  
  

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