School of Medicine Basic Sciences departments

Biochemistry

• Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states. Nature Communications.
  Brian MacTavish* (Scripps Research), Di Zhu* (Scripps Research), Qianzhen Shao, Zhongyue Yang, Douglas Kojetin*.
  
  
• Drugging Challenging Cancer Targets Using Fragment-Based Methods. Chemical Reviews.
  Stephen Fesik*.
  
  

Cell and Developmental Biology

• Characterization and comparison of temperature-sensitive Schizosaccharomyces pombe mutants of the septation initiation network scaffolds, Cdc11 and Sid4. microPublication Biology.
  Lesley Turner*, Anna Bowman Fletcher, Alaina Willet, Kathleen Gould*.
  
  
• Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia. Journal of Pathology.
  Emily Green*, Subhag Kotrannavar, Megan Rutherford, Hannah Lunnemann, Harsimran Kaur, Cody Heiser, Alan Simmons, Xiao Liu, Borden Lacy, M. Kay Washington, Martha Shrubsole, Qi Liu, Ken Lau, Robert Coffey, Nicholas Markham*.
  
  
• Dicer Loss in Müller Glia Leads to a Defined Sequence of Pathological Events Beginning With Cone Dysfunction. Investigative Ophthalmology & Visual Science.
  Daniel Larbi* (The State University of New York College of Optometry), Sabine Fuhrmann.
  
  
• Ribosome-directed cancer therapies: the tip of the iceberg? Trends in Pharmacological Sciences.
  Gregory Howard*, William Tansey*.
  
  

Molecular Physiology and Biophysics

• A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes. Cardiovascular Diabetology.
  Justin Gregory*, T. Jordan Smith, Sara Duffus, David Brooks, M. Naweed Akbar, Margaret-Anne Huntley, JoAnn Gottlieb, Lauren LeStourgeon, Christopher Wilson, Alan Cherrington*.
  
  Supported by the Vanderbilt Mouse Metabolic Phenotyping Center.
  

Pharmacology

• Large variability in the alkaloid content of Corydalis yanhusuo dietary supplements. Frontiers in Pharmacology.
  Paula Luis*, Claus Schneider*.
  
  School of Medicine Basic Sciences: Study uncovers significant differences in a dietary supplement’s key ingredient.
  
  
• Hederagenin is a Highly Selective Antagonist of the Neuropeptide FF Receptor 1 that Reveals Mechanisms for Subtype Selectivity. Angewandte Chemie.
  Hannah Lentschat* (Leipzig University), Claiborne Tydings, Jens Meiler.
  
  
• Self-supervised machine learning methods for protein design improve sampling but not the identification of high-fitness variants. Science Advances.
  Moritz Ertelt* (Leipzig University Faculty of Medicine), Rocco Moretti, Jens Meiler.
  
  
• Computational Engineering of siderocalin to modulate its binding affinity to the antihypertension drug candesartan. Journal of Structural Biology.
  Kristina Vogel* (Leipzig University), Johanna Moeller* (Leipzig University), Nina Bozhanova, Markus Voehler, Jens Meiler.
  
  Supported by the Vanderbilt High-Throughput Screening Facility.
  
  
• Long-Range Electrostatics in Serine Proteases: Machine Learning-Driven Reaction Sampling Yields Insights for Enzyme Design. Journal of Chemical Information and Modeling.
  Alexander Zlobin* (Leipzig University), Jens Meiler.
  
  
• Identification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus. Bioorganic & Medicinal Chemistry.
  Lorenz Beckmann* (Leipzig University), Jens Meiler.
  

Other basic biomedical research papers

• Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction. Nature Genetics.
  Guochong Jia, Jie Ping, Xingyi Guo, Yaohua Yang, Ran Tao, Bingshan Li, Tuya Pal, Qiuyin Cai, Jirong Long, Julie Palmer, Wei Zheng.
  
  Scientific American: Genetic Discoveries Could Reduce Black Women’s Higher Breast Cancer Death Risk

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