The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
Week of June 23
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Department of Biochemistry- Cytochrome P450BM-3 and P450 11A1 retain Compound I (FeO3+) chemistry with electrophilic substrates poised for Compound 0 (Fe3+O2-) reactions. Journal of Biological Chemistry.
Kevin McCarty*, Yasuhiro Tateishi, F. Peter Guengerich*.
Supported by the Mass Spectrometry Research Center.
- The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii. PLOS Pathogens.
Jeanette Critchlow*, Joseph Rocchio* (Indiana University), Melanie McKell, Juan Barraza, Evan Krystofiak, Erin Green, Tae Akizuki, Walter Chazin, Eric Skaar*.
- A first-in-class EGFR-directed KRAS G12V selective inhibitor. Cancer Cell.
Lyla Stanland* (EnFuego Therapeutics, Inc), Hayden Huggins* (EnFuego Therapeutics, Inc), Pradeep Pallan, Martin Egli.
- 5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells. Journal of Biological Chemistry.
Suhas Kharat*, Walter Chazin.
Department of Cell and Developmental Biology- A lipid atlas of the human kidney. Science Advances.
Melissa Farrow*, Léonore Tideman* (Delft University of Technology), Elizabeth Neumann*, Nathan Patterson, Madeline Colley, Jamie Allen, Ellie Pingry, Martin Dufresne, Haichun Yang, Maya Brewer, Emilio Rivera, Carrie Romer, Katerina Djambazova, Kavya Sharman, Angela Kruse, Danielle Gutierrez, Raymond Harris, Agnes Fogo, Mark de Caestecker, Richard Caprioli, Raf Van de Plas*, Jeffrey Spraggins*.
School of Medicine Basic Sciences: Kidney atlas maps molecular landscape, unlocking clues to renal health and disease
- Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics. Journal of Visualized Experiments: Bioengineering.
Matthew Rogers*, Laura Richardson, Marija Zanic*.
- Safety and efficacy of MEK inhibitor treatment for gastric pre-cancerous lesions. Gastroenterology.
James Goldenring*, Eunyoung Choi.
VUMC News: Drug shows safety, efficacy for precancerous stomach lesions
- SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis. JCI Insight.
Nina Bögershausen* (University Medical Center Göttingen), Büsranur Cavdarli* (Ankara Bilkent City Hospital), Taylor Nagai, Dharmendra Choudhary, Ela Knapik.
VUMC News: Tiny zebrafish aid discovery of rare, fatal genetic disease
Department of Molecular Physiology and Biophysics- Microglia are required for developmental specification of AgRP innervation in the hypothalamus of offspring exposed to maternal high-fat diet during lactation. eLife.
Haley Mendoza-Romero*, Jessica Biddinger, Michelle Bedenbaugh, Richard Simerly*.
- Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell Identity. Diabetes.
Anna Osipovich*, Matthew Dickerson, Jean-Philippe Cartailler, Shristi Shrestha, Nicole Wright, David Jacobson, Mark Magnuson*.
Supported by Creative Data Solutions.
- Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis. Arteriosclerosis, Thrombosis and Vascular Biology.
Azuah Gonzalez*, Cristina Youwakim, Brenda Leake, Kristin Fuller, S. M. Jamshedur Rahman, Matthew Dungan, Katherine Gu, Ashley Cavnar, Danielle Michell, Lindsay Davison, Calliope Cutchins, Yunli Chu, Zachary Kohutek, MacRae Linton, P. Brent Ferrell, Kasey Vickers, Meena Madhur, Jonathan Brown, Amanda Doran*.
VUMC News: VUMC team finds potential target to slow atherosclerosis
Department of Pharmacology
- Proteostasis landscapes of cystic fibrosis variants reveal drug response vulnerability. Proceedings of the National Academy of Sciences.
Eli Fritz McDonald*, Minsoo Kim, John Olson III, Jens Meiler*, Lars Plate*.
Supported by the Mass Spectrometry Research Center.
School of Medicine Basic Sciences: New research offers promise for treatment-resistant cystic fibrosis patients
- The role of arrestin-1 N-edge in rhodopsin binding. Cellular Signaling.
Sergey Vishnivetskiy*, Eugenia Gurevich, Vsevolod Gurevich*.
- Molecular basis for Gβγ-SNARE mediated inhibition of synaptic vesicle fusion. Journal of Biological Chemistry.
Anna Eitel*, Benjamin Mueller, Ali Kaya, Montana Young, Jackson Cassada, Eric Bell, Lauren Schnitkey, Zack Zurawski, Yun Yim, Qiangjun Zhou, Jens Meiler, Heidi Hamm*.
- Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice. BMC Biology.
Brianna Cellini* (Duke University), Valentina Cigliola*.
School of Medicine Basic Sciences:Unlocking the secrets of spinal cord regeneration
- The origin of hydroxy-cyclohexenone fatty acids from skin barrier protein and relevance to covalent binding of ceramides. Journal of Lipid Research.
Saori Noguchi*, William Boeglin, Fumie Nakashima, Donald Stec, M. Wade Calcutt, Alan Brash*.
- Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates. Nature Biomedical Engineering.
Blaise Kimmel*, Karan Arora, Neil Chada, Vijaya Bharti, Alexander Kwiatkowski, Jonah Finkelstein, Ann Hanna, Emily Arner, Taylor Sheehy, Lucinda Pastora, Jinming Yang, Hayden Pagendarm, Payton Stone, Ebony Hargrove-Wiley, Brandie Taylor, Lauren Hubert, Barbara Fingleton, Katherine Gibson-Corley, Jody May, John McLean, Jeffrey Rathmell, Ann Richmond, W. Kimryn Rathmell, Justin Balko, John T. Wilson*.
Supported by the Center for Structural Biology, the Mass Spectroscopy Research Center, and the Cell Imaging Shared Resource.
School of Engineering: Nanobody hitchhikers boost immunotherapy potency in cancer treatment
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Other basic biomedical papers- How the Structure of Signaling Regulation Evolves: Insights From an Evolutionary Model. Molecular Biology and Evolution.
Danial Asgari*, Ann Tate*.
Evolution@Vanderbilt: A Conservative Defense: Downstream NFLs Resist Evolutionary Blitzes
- Single-cell profiling demonstrates the combined effect of wheeze phenotype and infant viral infection on airway epithelial development. Science Advances.
Sergejs Berdnikovs* (Northwestern University Feinberg School of Medicine), Dawn Newcomb*, Kaitlin McKernan, Shelby Kuehnle, Tebeb Gebretsadik, Siyuan Ma, Jacqueline-Yvonne Cephus, Christian Rosas-Salazar, Tina Hartert.
VUMC News: VUMC-led research a step closer to understanding, preventing asthma
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First or corresponding authors are identified with an *. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.
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