Human and HPV Genes Form Extrachromosomal DNA That Promotes Oropharyngeal Tumor Growth
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A groundbreaking study led by Moores Member Joseph Califano, MD reveals that human and HPV genes can combine to form circular extrachromosomal DNA, which fuels tumor growth and immune evasion. Learn More>>
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How RNA Research Could Transform Medicine, If We Let It
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Moores Member Gene Yeo, PhD studies RNA molecules—tiny yet powerful players in human biology. Research from his laborator reveals how RNA not only shapes our biology, but also contributes to many diseases, which shapes future therapies. Learn More>>
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Moores Member Shapes Clinical Research and Care
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Moores Member Rebecca Shatsky, MD is a national leader in breast cancer care who drives innovation in precision medicine and clinical trials and advocates for young survivors. Her experience in completing a fellowship program at UC San Diego exemplifies what happens when opportunity meets determination. Learn More>>
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Moores Cancer Center Now on LinkedIn
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Follow Moores on LinkedIn to not only keep up-to-date with recent research and news, but also engage the Moores community. View LinkedIn Page>>
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Join the Curebound Cancer Challenge
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Building on the legacy of Padres Pedal the Cause, all funds raised through the Curbound Cancer Challenge will support collaborative cancer research. This year’s challenge will take place on August 2, 2025 at UC San Diego and feature new cycling routes and events, such as a 10K run and a 5K walk. Register Here>>
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| Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation
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Bing Ren, PhD (Structural and Functional Genomics)
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Development and validation of an artificial intelligence digital pathology biomarker to predict benefit of long-term hormonal therapy and radiotherapy in men with high-risk prostate cancer across multiple phase III trials
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Journal of Clinical Oncology
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Rana R. McKay, MD (Solid Tumor Therapeutics)
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| Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation
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Jing Yang, PhD (Cancer Biology and Signaling) and Trey Ideker, PhD (Structural and Functional Genomics)
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CLINICAL TRIALS OFFICE (CTO) |
EA8192: A Phase II/III Trial of Durvalumab and Chemotherapy for Patients with High Grade Upper Tract Urothelial Cancer Prior to Nephroureterectomy
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PI: Aditya Bagrodia, MD, FACS
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BMS CA209-1451: A Randomized Phase II Trial of Neoadjuvant Opdualag Versus Nivolumab for Resectable High-Risk Basal Cell Carcinoma
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S2303: Randomized Phase II/III Trial of 2nd-Line Nivolumab Paclitaxel Ramucirumab Versus Paclitaxel Ramucirumab in Patients with PDL1 CPS / 1 Advanced Gastric and Esophageal Adenocarcinoma (PARAMUNE)
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PI: Aaron Miller, MD, PhD
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2618-001: AKTive001: A Phase I/Ib Multiple Cohort Trial of ALTA2618 in Patients with Advanced Solid Tumors with AKT1 E17K Mutation
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SHARED RESOURCE SPOTLIGHT |
The Moores TCMSR provides state-of-the-art services using CRISPR/Cas9 technology to generate genetically modified mouse models, such as knocked-out, knocked-in, and conditionally targeted mice. Other TCMSR services include mouse ESCs targeting, blastocyst microinjection of ESCs, the production of traditional transgenic mice via DNA pronuclear microinjection, embryo and sperm cryopreservation, in vitro fertilization, and mice rederivation from frozen embryos and sperm. Contact TCMSR>>
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MOORES CANCER CENTER AT AACR |
At the AACR Annual Meeting 2025, taking place from April 25 — 30, 2025 in Chicago, IL, our physician-scientists will present key findings on immunology, computational biology and early detection and prevention through more than 30 sessions.
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Science in Session: Albert Hsiao, MD, PhD |
Learn more about the innovative research that Dr. Hsiao's team, with the help of visiting faculty, hopes will provide insights into non-small cell lung cancer (NSCLC) prevalence in Taiwanese populations and expand lung cancer screening access.
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COMMUNITY OUTREACH AND ENGAGEMENT (COE)
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Health Summit 2025 with the UC San Diego Pilipino Undergraduate Society for Health
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This year's summit "Building a Healthy World Together!" took place April 4–5, 2025. COE’s Krzel Manansala-Tan was the keynote speaker, who presented COE efforts to address cancer disparities, promote health equity, and reduce community disparities.
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14th Annual AMSA Free Health Fair
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COE attended the fair in South Bay that featured free health screenings, educational resources, wellness activities, local organizations, and live entertainment. COE provided cancer prevention and awareness resources.
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