Forwarded by the Los Angeles County Department of Public Health
Forwarded by the Los Angeles County Department of Public Health
CDC Health Advisory:
First Case of Clade I Mpox Diagnosed in the United States
November 19, 2024
The Centers for Disease Control and Prevention (CDC) has issued a Health Advisory to provide information about the first case of clade I mpox diagnosed in the United States and recommendations to clinicians about preventing, diagnosing, treating, and reporting mpox cases. The case, confirmed by the California Department of Public Health (CDPH), had recently traveled to areas experiencing clade I monkeypox virus (MPXV) transmission and sought medical care for mpox symptoms in the United States. Historically, clade I has caused more severe illness than clade II, however, recent infections from clade I mpox may not be as clinically severe as in previous outbreaks, especially when cases have access to quality medical care. The overall risk of clade I mpox to the general population in California and the United States continues to be low.
Clinicians should notify their local public health department if they have a patient with mpox-like symptoms and recent travel to Central or Eastern Africa. Public Health will coordinate MPXV clade-specific testing
Los Angeles County DPH Division of HIV and STD Programs:
  • Weekdays 8:00 am–5:00 pm: call 213-368-7441.
  • After-hours: call 213-974-1234 and ask for the physician on call.
Long Beach Health and Human Services:
  • Weekdays 8:00 am-5:00 pm: call 562-570-4302.
  • After hours: call the duty officer at 562-500-5537.
Pasadena Public Health Department:
  • Weekdays 8:00 am-5:00 pm: call 626-744-6089.  
  • After hours: call 626-744-6043.
Vaccines (e.g., JYNNEOS, ACAM2000) and other medical countermeasures (e.g., tecovirimat, brincidofovir, and vaccinia immune globulin intravenous) are available and expected to be effective for both Clade I and Clade II MPXV infections. Clinicians should encourage vaccination for patients who are eligible.
Visit the LAC DPH mpox provider hub for local resources related to vaccination, testing, treatment, and reporting.
Read the full CDC Health Advisory
View as PDF. You can also copy and paste this link into your browser: https://emergency.cdc.gov/han/2024/han00519.asp
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