Recently published

• GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data. Neuro-Oncology.
  Shoaib Ajaib (University of Leeds), Asa Brockman, Rebecca Ihrie.
  
  
• Identifying problematic opioid use in electronic health record data: Are we looking in the right place? Journal of Opioid Management.
  Lori Schirle, Shinwho Kwun, Ashley Suh, Alvin Jeffery, David Samuels.
  
  
• Harnessing prostaglandin E2 signaling to ameliorate autoimmunity. Trends in Immunology.
  Juliann Burkett, Amanda Doran, Maureen Gannon.
  
  “Beyond excited to announce the publication of my first ever first-author paper!! 🤩" - Juliann Burkett
  
  
  
• Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging. Cell Reports.
  Burak Uzay, Aiden Houcek, Zack Ma, Christine Konradi, Lisa Monteggia, Ege Kavalali.
  
  “I’m very excited to share my postdoc opus magnum, just got published in Cell Reports,” - Burak Uzay
  
  
  
• Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor. Cell Reports.
  Kelsey Pilewski (now at the Food and Drug Administration), Steven Wall, Elad Binshtein, Rohit Venkat, Andrea Shiakolas, Ian Setliff, Naveen Suryadevara, John Brannon, Connor Beebout, Nagarajan Raju, Lauren Walker, Emilee Friedman Fechter, Juliana Qin, Amyn Murji, Robert Carnahan, Maria Hadjifrangiskou, James Crowe Jr., Spyros Kalams, Ivelin Georgiev.
  
  "SO excited to share this (hugely collaborative) study!" - Kelsey Pilewski
  
  
  
• Using a semi-automated approach to quantify Unidentified Bright Objects in Neurofibromatosis type 1 and linkages to cognitive and academic outcomes. Magnetic Resonance Imaging.
  Emily Harriott, Tin Nguyen, Bennett Landman, Laura Barquero, Laurie Cutting.
  
  "Grateful for this great team of co-authors!!" - Emily Harriot
  

Preprints

• Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities. bioRxiv.
  Andrew Patterson, Gabriel Needle, Ayaka Sugiura, Channing Chi, KayLee Steiner, Emilie Fisher, Gabriella Robertson, Caroline Bodnya, Janet Markle, Vivian Gama, Jeffrey Rathmell.
  
  "Great work by Andrew Patterson to show IEI & IEM share more than previously known—a CRISPR resource for new immunometabolic genes," - Jeffrey Rathmell
  

Highlighted across the web

• Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion. Molecular Metabolism.
  Liu Yang, Margret Fye, Bingyuan Yang, Zihan Tang, Yue Zhan, Sander Haigh, Brittney Covington, Kai Bracey, Justin Tarask, Irina Kaverina, Shen Qu, Wenbiao Chen.
  Highlighted on the Basic Sciences website.
  
  
• LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8. Nature Cell Biology.
  Ryan Allen (University of Arkansas for Medical Sciences), Danielle Michell, Ashley Cavnar, Wanying Zhu, Neil Makhijani, Danielle Contreras, Chase Raby, Elizabeth Semler, Carlisle DeJulius, Mark Castleberry, Youmin Zhang, Marisol Ramirez-Solano, Shilin Zhao, Craig Duvall, Amanda Doran, Quanhu Sheng, MacRae Linton, Kasey Vickers.
  Highlighted in the VUMC Reporter.
  
  
• Compendium of proteins containing segments that exhibit zero-tolerance to amino acid variation in humans. Protein Science.
  Adam Sanders, Jake Hermanson, David Samuels, Lars Plate, Charles Sanders.
  Highlighted on the Basic Sciences website.

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