The Centers for Disease Control and Prevention (CDC) issued a Health Update to provide guidance on improving the use of therapeutics for the treatment of COVID-19 and strategies to prevent serious outcomes of COVID-19. Included in this CDC guidance are the following important points:
- Bebtelovimab is no longer authorized for treatment of COVID-19 due to the current high prevalence of Omicron variants that are resistant to this monoclonal antibody treatment.
- There is also a high level of variants that are resistant to Evusheld (the monoclonal antibody combination, cilgavimab and tixagevimab). Despite this, because Evusheld is the only agent authorized as pre-exposure prophylaxis (PrEP), it continues to be recommended for people who are not expected to mount an adequate immune response to COVID-19 vaccination or those with contraindications for COVID-19 vaccines. Providers should make sure patients receiving Evusheld are aware of the potential for reduced effectiveness and should emphasize the need for additional prevention measures such as wearing a high-quality well-fitting mask around others and that their household members and other close contacts stay up to date with vaccinations, including getting the bivalent booster.
- All three of the antiviral therapeutics for the treatment of COVID-19 retain activity against currently circulating Omicron sublineages. These medications (ritonavir-boosted nirmatrelvir [Paxlovid™], remdesivir [Veklury®], and molnupiravir [Lagevrio™] can prevent severe disease, hospitalization, and death and are widely available but have been underused.