Recently published

• An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism. Cell Host & Microbe.
  Catherine Shelton, Elizabeth Sing, Jessica Mo, Nicolas Shealy, Woongjae Yoo, Julia Thomas, Gillian Fitz, Pollyana Castro, Tara Hickman, Teresa Torres, Nora Foegeding, Jacob Zieba, Wade Calcutt, Simona Codreanu, Stacy Sherrod, John McLean, Sun Peck, Fan Yang, Nicholas Markham, Mariana Byndloss.
  
  
  “antibiotic-induced disruption of beneficial microbiota & epithelium interactions in the small intestine promotes obesity during early-life,” Mariana Byndloss.
  
  
• Spatially non-overlapping Ca2+ signals drive distinct forms of neurotransmission. Cell Reports.
  Camille Wang, Lisa Monteggia, Ege Kavalali.
  
  
  “We use optical imaging to examine the spatial organization of presynaptic calcium signals," Camille Wang.
  
  
• Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast. PLOS Genetics.
  Alaina Willet, Marcin Wos, Maya Igarashi, Liping Ren, Lesley, Turner, Kathleen Gould.
  
  
  “Check out our study on the interplay of complex sphingolipids
  (MIPC in the PM and building and maintaining a cell wall,” Gould lab.
  
  
• In-Cell Arrestin-Receptor Interaction Assays. Current Protocols.
  Chen Zheng, Prashant Donthamsetti, Vsevolod V. Gurevich.
  
  
• Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical Research in Toxicology.
  Haruna Nagayoshi (Osaka Institute of Public Health), F. Peter Guengerich.
  
  
• The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms. Cell Reports.
  Duy Lan Huong Bui, Andrew Roach, Elizabeth Orput, Ritika Raghavan, Richard Sando.
  
  
• RTEL1 and MCM10 overcome topological stress during vertebrate replication termination. Cell Reports.
  Lillian Campos, Sabrina Van Ravenstein, Emma Vontalge, Briana Greer, Darren Heintzman, Tamar Kavlashvili, Hayes McDonald, Kristie Lindsey Rose, Brandt Eichman, James Dewar.
  
  
• Non-canonical functions of a mutant TSC2 protein in mitotic division. PLOS One.
  Mary-Bronwen Chalkley, Rachel Mersfelder, Laura Armstrong, Rebecca Ihrie , Kevin Ess.
  
  
• Cytochrome P450 enzymes as drug targets in human disease. Drug Metabolism And Disposition.
  F. Peter Guengerich.
  
  
• The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. Nature Communications.
  Victoria Ng, Zachary Spencer, Leif Neitzel, Matthew Loberg, Sara N. Kassel, Heather Kroh, Christin Anthony, Jamal Bryant, Amanda Lawson, Lily Goldsmith, Amanda Hansen, Jingjing Li, Starina D’Souza, Ethan Lee.
  

Preprints

• Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose. bioRxiv.
  Amber Crabtree, Kit Neikirk, Aaron Whiteside, Jessica McKenzie, Zer Vue, Larry Vang, Trinity Celeste Owens, Ashton Oliver, Faben Zeleke, Heather K. Beasley, Estevão Scudese, Alice Koh, Suzanne Navarro, Ho-Jin Koh, Elma Zaganjor, Steven M. Damo, Jennifer A. Gaddy, Andrea G. Marshall, Antentor Hinton Jr.
  
  
• Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog. bioRxiv.
  Katie Coate, Marta Smith, Guillaume Kraft, Ben Farmer, Patrick Donahue, Alan Cherrington, Dale Edgerton.
  

Highlights from the web

• NKG2A is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple Negative Breast Cancer. Cancer Discovery.
  Brandie Taylor, Xiaopeng Sun, Paula Gonzalez-Ericsson, Violeta Sanchez, Melinda Sanders, Elizabeth Wescott, Susan Opalenik, Ann Hanna, Shu-Ting Chou, Luc Van Kaer, Brian Lehmann, Vandana Abramson, Jennifer Pietenpol, Justin Balko.
  
  
  Highlighted in the VUMC Reporter.
  
  
• Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division. Nature Immunology.
  Michael Rudloff, Natalie Favret, Jessica Roetman, Carlos Detrés Román, Megan Erwin, Kristen Murray, Sriya Jonnakuti, Mary Philip.
  
  Highlighted in the VUMC Reporter.
  

Editorial

• Editorial: making the invisible visible in STEMM. Pathogens and Disease.
  Antentor Hinton, Jr.
  

In the media

• Q&A With Dylan Burnette: Muscle Cells, Cell Movement, and Microscopy. Biomedical Beat Blog, National Institute of General Medical Sciences.
  Kimberly Rousseau.

Conference proceedings

• Topological-preserving membrane skeleton segmentation in multiplex immunofluorescence imaging. Proceedings Volume 12471, Medical Imaging 2023: Digital and Computational Pathology; 124710B (2023). SPIE Digital Library.
  Shunxing Bao, Can Cui, Jia Li, Yucheng Tang, Ho Hin Lee, Ruining Deng, Lucas W. Remedios, Xin Yu, Qi Yang, Sophie Chiron, Nathan Heath Patterson, Ken S. Lau, Qi Liu, Joseph T. Roland, Lori A. Coburn, Keith T. Wilson, Bennett A. Landman, Yuankai Huo.
  

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