The Grant Game

School of Medicine Basic Sciences departments

Biochemistry

• Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification. Cell Reports.
  Lindsey Guerin*, Timothy Scott, Jacqueline Yap, Yilin Yang, Alan Simmons, Ken Lau, Rebecca Ihrie, Emily Hodges*.
  
  School of Medicine Basic Sciences: Gene expression during differentiation depends on timing of epigenetic changes
  
  
• Use of Xenopus Egg Extracts to Study the Effects of Topoisomerase Poisons During Vertebrate DNA Replication (book chapter). Methods in Molecular Biology: Topoisomerases: Methods and Protocols.
  Sabrina Van Ravenstein*, James Dewar*.
  
  
• DNA Cleavage Mediated by Bacterial Type II Topoisomerases (book chapter). Methods in Molecular Biology: Topoisomerases: Methods and Protocols.
  Chelsea Mann*, Neil Osheroff*.
  
  
• DNA Supercoiling Catalyzed by Bacterial Gyrase (book chapter). Methods in Molecular Biology: Topoisomerases: Methods and Protocols.
  Samika Joshi*, Neil Osheroff*.
  
  
• DNA Decatenation Catalyzed by Bacterial Topoisomerase IV (book chapter). Methods in Molecular Biology: Topoisomerases: Methods and Protocols.
  Jillian Armenia*, Neil Osheroff*.
  
  
• Modulation of TTR gene expression in the eye using modified siRNAs. Nucleic Acids Research.
  Jiaxin Hu* (UT Southwestern Medical Center), Martin Egli.
  
  
• A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site. Proceedings of the National Academies of Science of the United States of America.
  Christopher Williams* (Scripps Research), Paola Munoz-Tello, Douglas Kojetin*.

Cell and Developmental Biology

• Good things come in threes: Distinct C. elegans basement membranes utilize novel collagen IV trimers. Journal of Cell Biology.
  K Elkie Peebles*, Andrea Page-McCaw*.
  
  
• Characterization of temperature-sensitive alleles of the septation initiation network protein Mob1 in Schizosaccharomyces pombe. microPublication Biology.
  Sarah Hanna*, Alaina Willet, Kathleen Gould*.
  
  
• The Schizosaccharomyces pombe nucleolar protein Nsk1 modulates rDNA silencing during interphase. microPublication Biology.
  Jun-Song Chen*, Sarah Hanna, Alaina Willet, Kathleen Gould*.

Molecular Physiology and Biophysics

• GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice. Nature Communications.
  Rhianna Laker* (AstraZeneca), Shaun Egolf* (AstraZeneca), Louise Lantier, Owen McGuinness.
  
  Supported by the Vanderbilt Mouse Metabolic Phenotyping Center.

Pharmacology

• Enhanced ERK activity extends ketamine's antidepressant effects by augmenting synaptic plasticity. Science.
  Z. Zack Ma*, Natalie Guzikowski, Ji-Woon Kim, Ege Kavalali, Lisa Monteggia*.
  
  School of Medicine Basic Sciences: New ketamine study promises extended relief for depression
  

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