The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
Week of July 21
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Department of Biochemistry- The XNA alphabet. Nucleic Acids Research.
John Chaput* (University of California, Irvine), Martin Egli.
- Glycolipids implicated as mediators of clinically visible retinal pigment epithelial migration in age-related macular degeneration. PNAS.
Zhen Wang*, David Anderson*, Kevin Schey*.
- Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib. Science Signaling.
Serena Muratcioglu*, Chien-Lun Hung, John Kuriyan*.
- The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity. Cell Genomics.
Emeli Chatterjee* (Massachusetts General Hospital), Michael Betti*, Quanhu Sheng*, Phillip Lin, Kaushik Amancherla, Charles Flynn, Jonathan Brown, Danxia Yu, Eric Gamazon, Ravi Shah.
VUMC News: Multidisciplinary study develops tools for new ‘genomics of interorgan communication’
Department of Cell and Developmental Biology- MYC Regulates a DNA Repair Gene Expression Program in Small Cell Carcinoma of the Ovary, Hypercalcemic Type. Cancers.
James Evans*, Jing Wang, Cinthia Reed, William Tansey, Qi Liu.
- P4-ATPases control phosphoinositide membrane asymmetry and neomycin resistance. Nature Cell Biology.
Bhawik Jain*, H. Diessel Duan*, Christina Valentine, Ariana Samiha, Huilin Li, Todd Graham*.
Supported by the Cell Imaging Shared Resource.
- Fortilin deficiency induces anti-atherosclerotic phenotypes in macrophages and protects hypercholesterolemic mice against atherosclerosis. Communications Biology.
Nattaporn Wanachottrakul* (University of Texas Medical Branch at Galveston), Decha Pinkaew* (University of Texas Medical Branch at Galveston), Sandipan Mukherjee* (University of Washington), Preedakorn Chunhacha* (University of Texas Medical Branch at Galveston), Asa Brockman, Rebecca Ihrie.
Supported by the Vanderbilt Brain Institute.
- α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture. Proceedings of the National Academies of Science of the United States of America.
Anand Jacob* (Michigan State University), Alaina Willet*, Maya Igarashi, Lesley Turner, Kathleen Gould*.
Supported by the Cell Imaging Shared Resource.
Department of Molecular Physiology and Biophysics- IL31 Identified as a Key Genetic Risk Factor for Prurigo Nodularis. Journal of Allergy and Clinical Immunology.
Matthew Patrick* (University of Michigan Medical School), Xue Zhong, Bingshan Li.
- Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci. International Journal of Cancer.
Guochong Jia*, Jie Ping, Ran Tao, Jirong Long, Lili Liu, Shuai Xu, Heather Munro, Tuya Pal, Sonya Reid, Bingshan Li, Xiao-Ou Shu, Xingyi Guo, Wei Zheng*.
Department of Pharmacology- Overexpression of mGlu7B in Mice: Implications for Neurodevelopmental Disorders. Molecular Neurobiology.
Geanne Freitas*, Kelly Weiss*, Vaishnavi Bavadekar*, Sheryl Vermudez, Nicole Fisher, Aditi Buch, Shalini Dogra, Zixiu Xiang, Rocco Gogliotti, Colleen Niswender*.
Supported by the Cell Imaging Shared Resource and the Mouse Neurobehavioral Core.
- Discovery of a Novel sp3-Rich M1 Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping. ACS Medicinal Chemistry Letters.
Joseph Bungard*, Paul Spearing, Yu Nishio, Upendra Rathnayake, Chris Presley, Sichen Chang, Haley Kling, Analisa Thompson, Hyekyung Cho, Li Peng, Alice Rodriguez, Colleen Niswender, Olivier Boutaud, Valerie Kramlinger, Carrie Jones, P. Jeffrey Conn, Julie Engers, Darren Engers*, Craig Lindsley*, Changho Han*.
- Cytoplasmic tail composition modulates the G protein and arrestin-3 signaling bias of the adhesion GPCR LPHN2 (preprint). bioRxiv.
Krassimira Garbett*, Chen Zheng, Vsevolod Gurevich, Richard Sando*.
- Loss of IL13RA2 promotes metastatic tumor growth in triple-negative breast cancer via increased AKT and NF-κB signaling. Clinical & Experimental Metastasis.
Wendy Bindeman*, Kevin Corn, Marjan Rafat, Barbara Fingleton*.
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First or corresponding authors are identified with an *. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.
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