New MBC Drug Approved; Discovered in McDonnell Lab
A potential gamechanger for ER+/HER2-, ESR1-mutated metastatic breast cancer patients, the FDA approved elacestrant (Orserdu) on Jan. 27. It's the first new and first oral endocrine therapy approved in 20+ years. Working in the McDonnell Lab, Suzanne Wardell, PhD, and Erik Nelson, PhD, elucidated its mechanism of action more than 10 years ago. READ
Moving Mountains in HER2+ Colorectal Cancer
John Strickler, MD, and team's milestone work on the "MOUNTAINEER" clinical trial has led to the first FDA-approved treat-ment regimen for patients with HER2+ metastatic colorectal cancer. Elle Charnisky (at right) was the first patient nationwide to be accrued back on Aug, 8, 2017. READ
Created by The Cancer Letter to mark the 50th anniversary of the National Cancer Act of 1971, the Cancer History Project is a free historical resource collaboratively curated by the institutions & people who shaped it — to be preserved in perpetuity for researchers, medical professionals, students, policymakers, and patients.
(Click on the photos below to read the individual articles; more to come)
Susan Dent, MD, co-authored a multi-institutional Scientific Statement on Cancer Therapy-Related Hypertension on behalf of the American Heart Association Council on Hypertension; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on the Kidney in Cardiovascular Disease. READ
Dent also co-authored, with Leah Zullig, PhD, MPH; and other DCI colleagues, one of the top 10 most read JACC CardioOncology articles in 2022: "Cardiometabolic Comorbidities in Cancer Survivors." READ
An Extraordinary Woman in Cardiothoracic Surgery
Duke Cancer Institute member Betty Tong, MD, BME, MSME, MD, MHS, has won the inaugural “Extraordinary Women in Cardiothoracic Surgery Award” established by the Society of Thoracic Surgeons and Women in Thoracic Surgery. The award celebrates those who have achieved excellence and innovation in clinical practice and who demonstrate integrity, leadership, mentorship, creativity, and advocacy. READ
New Duke OB/GYN Annual Magazine Commemorates DCI 50th & GynOnc Division 50th with Several Cancer-Related Articles
BLACK HISTORY MONTH at DCI
Keisha Bentley-Edwards, PhD, MA, a developmental psychologist, studies the causes and consequences of inequality and develops remedies for these disparities and their adverse effects. She talks about her thoughts on Black History Month and addresses its importance in medicine.
Julius Wilder, MD, PhD, a hepatologist, gastroenterologist, and medical sociologist, was the featured speaker for the Duke Department of Medicine 2023 Martin Luther King Jr. Memorial Medicine Grand Rounds, held Jan. 13. Wilder is a partner in DCI's community outreach efforts, including colorectal cancer screening advocacy. In this Q & A, conducted in Dec. 2022, he talks about his cancer disparities work and more.
Nurse Clydie Pugh-Myers' oral history was taken in 2006. It was a no holds barred conversation. A 1949 Duke LPN program grad, Pugh-Myers was in the first group of Black nurses to work in the white ward of a segregated Duke University Hospital.
In 2018, Joanne Wilson, MD, the first African American woman in Duke School of Medicine with tenure, interviewed Sadye Curry, MD, who trained at Duke and was the first African American woman gastroenterologist in the U.S.
The inaugural MaryAnn Black Distinguished Health Equity Lecture was hosted on Feb. 9, 2023, by the DCI Community Outreach, Engagement, and Equity program (COEE) in honor of the late MaryAnn Black, "for her extraordinary leadership, enduring impact, and powerful advocacy across the community." Black was a career social worker in Durham, North Carolina, who served on the County Board of Commissioners, worked as the associate vice president of community relations at Duke University Health System, and served in the North Carolina House of Representatives. Distinguished lecturer Marcella Nunez-Smith, MD, MHS, (associate director, Yale Cancer Center, and associate dean for Health Equity Research) presented "Health Equity in Action: Applying COVID-19 Lessons to the Cancer Equity March." WATCH
SC Man Develops Irish Brogue as Sign of Transformation to Small Cell NEPC
Have you ever heard of foreign accent syndrome? Andrew Armstrong, MD, MSc, recently spoke with Newsweek about a man he treated for metastatic hormone-sensitive prostate cancer who developed the rare syndrome when his cancer progressed to a more aggressive variant. The cancer spread to his brain a year later and he passed away. Armstrong, along with internal medicine resident Amanda Broderick, MD, oncologist Matthew Labriola, MD, and Neal Shore, MD, a urologist based in Myrtle Beach, first published on the unusual case in BMJ Case Reports. READ
Blobe Elected as AAAS Fellow
Gerard C. Blobe, MD, PhD, has been elected as a 2022 AAAS Fellow by the American Association for the Advancement of Science, one of the most distinct honors in the scientific community.
Blobe directs the DCI Office of Cancer Research Training Education Coordination. His lab focuses on TGF-ß signaling pathways in cancer biology and his clinical focus is GI cancers.
From Duke, Steven B. Haase, PhD, was also elected an AAAS Fellow. READ
NCI Features Hwang
In a new National Cancer Institute video, Shelley Hwang, MD, MPH, discusses the Human Tumor Atlas Network's (HTAN) role in facilitating a greater multi-dimensional understanding of cancer and its progression.
HTAN is a collaborative network that's constructing 3-dimensional atlases of the cellular, morphological, and molecular features of human cancers over time. This multi-institutional project addresses one of the Cancer Moonshot recommendations. WATCH
NIH Grant Awarded to Prep Students for Graduate & Medical Programs
“We're lacking in diversity of our biomedical sciences pipeline," says Gerard Blobe, MD, PhD. He and Micah Luftig, PhD, with Johnna Frierson, PhD, are co-investigators on a new $1.2M NIH grant-funded program aimed at helping to change this.
Together they will develop a one-year post-baccalaureate program for students from backgrounds historically underrepresented in science and medicine that are interested in pursuing a PhD or MD/PhD in the biomedical or basic sciences. READ
Two Jewish Women who Broke through Gender Barriers in Science
Gertrude "Trudy" Belle Elion: Drug Development Pioneer
Gertrude "Trudy" Belle Elion, an adjunct professor of Pharmacology & of Experimental Medicine at Duke (1971-1983) and research professor (1983-1999) at Duke pioneered an innovative approach to drug development for which she and colleagues won the 1988 Nobel Prize in Physiology or Medicine.
She discovered an anti-leukemia drug (6-MP), acyclovir against Herpes, and many more life-changing drugs. Her name appeared on 45 patents. READ
(strictly academic or clinical)
FEB. 22 (10a) : REGISTER: School of Nursing hosts "The Cost of Health Inequities and the Role of Nurses in the Future of Healthcare"
LOCATION: Christine Siegler Pearson Building, room 1014; and via Zoom.
FEB. 23 (12p to 1p): REGISTER: Michael J. Kelley, MD, talk on "VA Precision Oncology" (part of the Precision Medicine Program Forum Series) via Zoom
FEB. 23 (12p to 1p): Faculty Lectures by Debra Silver, PhD, and Craig Lowe, PhD
LOCATION: Great Hall, Trent Semans Center, and via Zoom
FEB. 23 (4p to 5p): "Telomeres and cancer: genome instability and tumor suppression" — the Robert J. Lefkowitz, MD, Distinguished Lecture featuring Titia de Lange, PhD, (Rockefeller University)
LOCATION: Great Hall, Trent Semans Center, and via Zoom
FEB. 24 (8a to 5p, including post-event reception): Precision Genomics Collaboratory (PGC) 2nd Annual Genomics Scientific Retreat
LOCATION: Great Hall, Trent Semans Center
(general public welcome)
Tomi Akinyemiju, PhD, (right), associate director, DCI Community Outreach, Engagement, and Equity (COEE) program, joined colleagues at an Executive Leadership in Academic Medicine (ELAM) event. ELAM prepares senior women faculty at schools of medicine, dentistry, public health and pharmacy and in hospital systems for institutional leadership positions.
In partnership with DCI, Duke Fencing students are asking the community to Fence4TheFight against breast cancer, in honor
of their long-time manager Elizabeth Beguinet. She passed away in December after a long battle with breast cancer.
With funds raised, the goal is to name a room at Duke Cancer Center in her memory. READ
DCI interventional radiologist Alan Sag, MD, (center), and DCI colleagues presented their multidisciplinary approach "One Stop Shop: The Management of Bone Metastasis Through an Osteo-Oncology Clinic" at the "Innovation & Collaboration: 2023 Advances in Musculo-skeletal Oncology Symposium." Below is a recent video on a similar theme. WATCH
Julie Poucher Harbin, Senior Writer, DCI, is Managing Editor of the DCI E-News & the DCI Blog.
FILL OUT THIS FORM to submit announcements of upcoming events; new faculty, fellows, or residents; honors, awards, recognitions, new roles, promotions; and other news you wish to share
for potential inclusion in the next DCI E-news or internal channels.
Copyright © 2023 Duke Cancer Institute, All rights reserved.
Manage your preferences | Opt Out using TrueRemove™
Got this as a forward? Sign up to receive our future emails.
View this email online.
20 Duke Medicine Circle | Durham, NC 27710 US
This email was sent to firstname.lastname@example.org.
To continue receiving our emails, add us to your address book.