Using Iron to Destroy Multiple Myeloma Cancer Cells
Duke researchers have discovered a way to potentially save lives by targeting a key enzyme that helps multiple myeloma cells survive and resist treatment. By blocking this enzyme, STK17B, the team not only killed cancer cells but also made them more responsive to existing therapies, offering hope for patients who face relapse or drug resistance. In mouse models, an oral version of the inhibitor significantly reduced tumor growth, pointing to a promising new therapeutic strategy. The findings could also pave the way for improving treatments against other cancers that resist standard therapies.
This research was supported by the National Institutes of Health.