School of Medicine Basic Sciences departments

Cell and Developmental Biology

• The postsynaptic density in excitatory synapses is composed of clustered, heterogeneous nanoblocks. Journal of Cell Biology.
  Rong Sun*, James Allen, Zhuqing Mao, Liana Wilson, Mariam Haider, Baris Alten, Zimeng Zhou, Xinyi Wang, Qiangjun Zhou*.
  
  Supported by the Cryo-EM Facility.
  
  
• Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression. Nature Communications.
  Shawyon Shirazi*, Nicholas Negretti, Christopher Jetter, Alexandria Sharkey, Shriya Garg, Devan Wilkins, Gabrielle Fortier, Christopher Wright, Jonathan Kropski*, Jennifer Sucre*.
  
  
• The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling. Nature Communications.
  Sara Kassel*, Kai Yuan* (Dartmouth College), Anna Schwarzkopf, Matthew Loberg, George Xu, Alex Cho, Mary Rockouski, Gemma Orton, Lily Goldsmith, Fei Ye, Vivian Weiss, Ethan Lee*.

Molecular Physiology and Biophysics

• Impact of Embryo Culture and Day of Embryo Transfer on the Cardiometabolic Health of Adult Mice. Biology of Reproduction.
  Rhodel Simbulan* (University of California San Francisco, San Francisco), Louise Lantier, Owen McGuinness.
  
  
• Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior. iScience.
  Serena Sweet*, Jessica Biddinger, Jessie Zimmermann, Gina Yu, Richard Simerly*.
  

Pharmacology

• Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice. BMC Biology.
  Brianna Cellini* (Duke University), Valentina Cigliola*.
  
  “A year of stem cell and developmental biology” Nature Collection: Featured in the “From aging to regeneration” section
  
  
• Advancements in Ligand-Based Virtual Screening through the Synergistic Integration of Graph Neural Networks and Expert-Crafted Descriptors. Journal of Chemical Information and Modeling.
  Yunchao Liu*, Rocco Moretti, Bailu Yan, Bobby Bodenheimer, Tyler Derr, Jens Meiler*.
  
  
• Similar Binding Mode of a 5-Sulfonylthiouracil Derivative Antagonist at Chemerin Receptors CMKLR1 and GPR1. Journal of Medicinal Chemistry.
  Tina Schermeng* (Leipzig University), C. David Weaver, Jens Meiler.
  
  Supported by the High-Throughput Screening Facility.
  
  
• Recent developments in cystic fibrosis drug discovery: where are we today? Expert Opinion on Drug Discovery.
  Miquéias Lopes-Pacheco* (Emory University), John Olson 3rd, Minsoo Kim, Kaitlyn Ledwitch, Jens Meiler, Lars Plate.
  
  
• Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity. Alzheimer’s & Dementia.
  Marissa Gogniat*, Omair Khan, Judy Li, W. Hudson Robb, Panpan Zhang, Yunyi Sun, Elizabeth Moore, Michelle Houston, Kimberly Pechman, Niranjana Shashikumar, L. Taylor Davis, Dandan Liu, Bennett Landman, Keith Cole, Corey Bolton, Katherine Gifford, Timothy Hohman, Kelsie Full, Angela Jefferson*.
  
  The Ledger–Nashville Edition: Study notes sedentary role in Alzheimer’s risk (scroll down for story)
  
  
• Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound. ACS Medicinal Chemistry Letters.
  Motoyuki Tanaka* (Ono Pharmaceutical Co.), Elizabeth Childress, Sean Bollinger, Trevor Chopko, Thomas Bridges, Douglas Stafford, Zhonping Huang, Mark Wolf, Darren Engers, Jerod Denton, Craig Lindsley*.
  
  and
  
  Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound. ACS Chemical Neuroscience.
  Kentaro Yashiro* (Ono Pharmaceutical Co.), Joshua Wieting, Kevin McGowan, Thomas Bridges, Olivier Boutaud, Darren Engers, Jerod Denton, Craig Lindsley*.
  
  School of Medicine Basic Sciences: New Warren Center TREK channel compounds reveal power of academic-industry partnerships in drug discovery
  
  
• Potentiation of group III metabotropic glutamate receptors positively affects neurophysiological features in a mouse model of Rett syndrome. The Journal of Pharmacology and Experimental Therapeutics.
  Hong-Wei Dong*, Kelly Weiss, Jonathan Dickerson, Mac Meadows, Irene Zagol-Ikapitte, Olivier Boutaud, Jerri Rook, Jeffrey Neul*, Colleen Niswender*.
  
  Supported by the Mouse Neurobehavioral Lab Core.
  
  
• Kaiso mediates transcription and RNA splicing in colorectal carcinoma: role of BRCA1 in the Kaiso enhanceosome. Open Biology.
  Weifeng Luo*, Qi Liu, Lei Chen, Chi Yan, Ann Richmond*, Albert Reynolds.
  

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