Recently published

• Modeling conformational states of proteins with AlphaFold. Current Opinion in Structural Biology.
  Davide Sala (University of Leipzig), Felipe Engelberger, Hassane Mchaourab, Jens Meiler.
  
  “[Hassane Mchaourab], [Jens Meiler] & collaborators analyze [AlphaFold] pipelines to expand the structural breadth of an ensemble or bias the prediction toward a desired conformational state of proteins,” Vanderbilt Center for Structural Biology.
  
  
• Re-Evaluating the Role of PTHrP in Breast Cancer. Cancers.
  Jeremy Kane, Rachelle Johnson.
  
  “The interest is in how the molecule is seemingly able to both promote and suppress tumor growth, undergo non-canonical nuclear entry, and bypass its own receptor on cancer cells,” Cancer Biology newsletter.
  
  
• Bioinformatics Screen Reveals Gli-Mediated Hedgehog Signaling as an Associated Pathway to Poor Immune Infiltration of Dedifferentiated Liposarcoma. Cancers.
  Erik Beadle, Natalie Bennett, Julie Rhoades.
  
  “Using a broad bioinformatics approach, we show that Hedgehog signaling, a developmental pathway, is upregulated in [dedifferentiated liposarcomas] and correlates with a tumor gene expression signature that suggests reduced immune cell infiltration and increased extracellular matrix (ECM) protein expression,” Erik Beadle.
  
  
• Heat stress and amphibian immunity in a time of climate change. Philosphical Transactions of the Royal Society B.
  Louise Rollins-Smith, Emily Le Sage.
  
  “A review from the Rollins-Smith Lab reviews the state of knowledge of how amphibians respond to some natural stressors, including heat and desiccation stress, and the limited studies of the immune [defense] under these stressful conditions,” VUMC Molecular Pathogenesis.
  
  
• Untargeted Lipidomic Profiling of Aged Human Retina With and Without Age-Related Macular Degeneration (AMD). Retinal Degenerative Diseases.
  Ankita Kotnala, David Anderson, Kevin Schey.
  
  
• High-Resolution Imaging Mass Spectrometry of Human Donor Eye: Photoreceptors Cells and Basal Laminar Deposit of Age-Related Macular Degeneration. Retinal Degenerative Diseases.
  David Anderson, Ankita Kotnala, Nathan Patterson, Jeffrey Spraggins, Richard Caprioli, Kevin Schey.
  
  
• Correction: Garza-Lopez et al. Protocols for Generating Surfaces and Measuring 3D Organelle Morphology Using Amira. Cells.
  Edgar Garza-Lopez, Zer Vue, Prasanna Katti (National Heart, Lung, Blood Institute), Heather Beasley, Andrea Marshall, Taylor Rodman, Larry Vang, Antentor Hinton Jr.
  
  
• Unified tumor growth mechanisms from multimodel inference and dataset integration. PLOS Computational Biology.
  Samantha Beik, Vito Quaranta, Carlos F. Lopez.
  

Preprints

• Mapping Niche-specific Two-Component System Requirements in Uropathogenic Escherichia coli. boiRxiv.
  John Brannon, Seth Reasoner, Tomas Bermudez, Taryn Dunigan, Michelle Wiebe, Connor Beebout, Tamia Ross, Adebisi Bamidele, Maria Hadjifrangiskou.

Highlighted across the web

• Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus. Science Immunology.
  Kelsey Voss, Allison Sewell, Evan Krystofiak, Katherine Gibson-Corley, Arissa Young, Jacob Basham, Ayaka Sugiura, Emily Arner, William Beavers, Dillon Kunkle, Megan Dickson, Gabriel Needle, Eric Skaar, Kimryn Rathmell, Michelle Ormseth, Amy Major, Jeffrey Rathmell.
  
  "A pre-clinical study in [Science Immunology] from [Vanderbilt Health] reveals that disrupting the ability of immune cells to take up iron can correct T cell dysfunction and reduce pathology,” Vanderbilt University Medical Center.
  
  Highlighted in VUMC's Discoveries in Medicine.
  
  
• Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study. Nature Medicine.
  Jeffrey Neul
  
  Highlighted in the VUMC Reporter.
  
  

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