By Basic Sciences department

Biochemistry

• Flexibility and Distributive Synthesis Regulate RNA Priming and Handoff in Human DNA Polymerase α-Primase. Journal of Molecular Biology.
  John Cordoba*, Elwood Mullins, Lauren Salay, Brandt Eichman, Walter Chazin*.
  
  Highlighted on the CSB Weekly Coordinates.
  
  
  
• Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nature Structural and Molecular Biology.
  
  Kendra Marcus*, Yongjian Huang*, Subu Subramanian, John Kuriyan*.
  
  

Cell and Developmental Biology

• Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain Signaling (preprint). bioRxiv.
  Hannah Jones (University of Colorado Anschutz Medical Campus)*, Gabriella Robertson, Alejandra Romero-Morales, Vivian Gama*.
  
  
• Engineering a CRISPRoff Platform to Modulate Expression of Myeloid Cell Leukemia (MCL-1) in Committed Oligodendrocyte Neural Precursor Cells. bio-protocol.
  Melanie Gil*, Catherine Hamann, Jonathan Brunger*, Vivian Gama*.
  
  
  

Molecular Physiology and Biophysics

• A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans. PLOS ONE.
  Justin Gregory*, Guillaume Kraft, James Slaughter, Melanie Scott, Jon Hastings, Dale Edgerton, Mary Moore, Alan Cherrington.
  
  
• Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner. Brain, Behavior and Immunity.
  Katrina Volk Robertson*, Michael Schleh, Fiona Harrison*, Alyssa Hasty*.
  
  
• Update on the Use of Pulse Wave Velocity to Measure Age-Related Vascular Changes. Current Hypertension Reports.
  Andrea Marshall*, Kit Neikirk*, Jeremiah Afolabi, Naome Mwesigwa, Bryanna Shao, Annet Kirabo, Antentor Hinton Jr.*

Other biomedical basic sciences papers

• B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan’s syndrome mutations. Proceedings of the National Academy of Sciences.
  Cheng-Guo Wu (University of Wisconsin at Madison), Brian Wadzinski.


• The Greatwall-Endosulfine-PP2A/B55 pathway controls entry into quiescence by promoting translation of Elongator-tuneable transcripts (preprint). Research Square.
  Javier Encinar del Dedo* (University of Salamanca), Kathleen Gould.
  
  
• Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity. Cell Metabolism.
  Benjamin Weidemann (Northwestern University)*, Louise Lantier, Owen McGuinness, Roland Stein.
  
  
• Dendritic cell epithelial sodium channel induced inflammation and salt-sensitive hypertension. Current Opinion in Nephrology and Hypertension.
  Mert Demirci*, Antentor Hinton Jr., Annet Kirabo*.
  
  
• Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice. Scientific Reports.
  Adriana Norris*, Eugenia Yazlovitskaya, Lin Zhu, Bailey Rose, Jody May, Katherine Gibson-Corley, John McLean, John Stafford, Todd Graham*.
  
  “We found a novel genetic factor that influences sex-specific fat metabolism using a mouse model,” Adriana Norris, Ph.D.
  
  
• Plasma Cell Differentiation, Antibody Quality, and Initial Germinal Center B Cell Population Depend on Glucose Influx Rate. The Journal of Immunology.
  Shawna Brookens*, Sung Hoon Cho*, Yeeun Paik, Kaylor Meyer, Ariel Raybuck, Chloe Park, Dalton Greenwood, Jeffrey Rathmell, Mark Boothby*.
  
  

  “Glucose metabolism is key in production of mature antibody-producing [B cells]; [Journal of Immunology] findings could point to targets to promote immune responses to vaccines or reduce [autoimmune] disease processes,” Insights @ VUMC.
  
  

  Highlighted in the VUMC Reporter.
  
  
• Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages. Cancer Research.
  Megan Tigue*, Matthew Loberg, Jeremy Goettel, Ethan Lee, Vivian Weiss*.
  
  Highlighted on the Basic Sciences website.
  
  
• Recent Advances in Understanding Peripheral and Gut Immune Cell-Mediated Salt-Sensitive Hypertension and Nephropathy. Hypertension.
  Mohammad Saleem, Jeanne Ishimwe, Mert Demirci, Taseer Ahmad, Sydney Jamison, Claude Albritton, Naome Mwesigwa, Alexandria Porcia Haynes, Jalyn White, Kit Neikirk, Zer Vue, Antentor Hinton Jr., Suha Arshad, Selam Desta, Annet Kirabo*.

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