The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
Week of February 10
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By Basic Sciences department Biochemistry Cell and Developmental Biology- Atf4 protects islet β-cell identity and function under acute glucose-induced stress but promotes β-cell failure in the presence of free fatty acid. Diabetes.
Mahircan Yagan*, Sadia Najam, Ruiying Hu, Yu Wang, Mathew Dickerson, Prasanna Dadi, Yanwen Xu, Alan Simmons, Roland Stein, David Jacobson, Ken Lau, Qi Liu, Guoqiang Gu*.
- Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A. Cell Reports.
Chen Shen* (Georgetown University), Wenhui Lu* (Georgetown University), Siva Merugu* (Georgetown University), Lauren Schnitkey, Carolina Cywiak, Ethan Lee.
Molecular Physiology and Biophysics- Phenotypic consequences of logarithmic signaling in MAPK stress response. iScience.
Hossein Jashnsaz*, Gregor Neuert*.
Supported by the Advanced Computing Center for Research and Education.
- The Role of Serum Free Fatty Acids in Endothelium-Dependent Microvascular Function. Endocrinology, Diabetes & Metabolism.
Alexander Sullivan*, Aaron Ada, David Wasserman, Kevin Niswender, Emily Shardelow, Emily Wells, Quinn Wells, Matthew Freiberg.
- E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells. Genes & Development.
Alexis Oguh* (University of Pennsylvania), Shristi Shrestha, Jean-Philippe Cartailler, Rafael Arrojo e Drigo.
Supported by the Advanced Computing Center for Research and Education and Creative Data Solutions.
- Creating Optimal Western Blot Conditions for OPA1 Isoforms in Skeletal Muscle Cells and Tissue. Current Protocols.
Margaret Mungai*, Amber Crabtree*, Han Le, Johnathan Moore, Desiree Nguyen, Benjamin Rodriguez, Chanel Harris, Dominique Stephens, Heather Beasley, Kit Neikirk, Bryanna Shao, Ashton Oliver, Genesis Wilson, Larry Vang, Zer Vue, Neng Vue, Andrea Marshall, Elma Zaganjor, Jennifer Gaddy, Celestine Wanjalla, Antentor Hinton Jr.*
Supported by the Cell Imaging Shared Resource.
- Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells. Current Protocols.
Amber Crabtree*, Han Le*, Chanel Harris*, Ashton Oliver*, Andy Barillas, Johnathan Moore, Desiree Ngoc-Ha Nguyen, Izabella Marie Rabago, Benjamin Rodriguez, Dominique Stephens, Heather Beasley*, Kit Neikirk, Margaret Mungai, Larry Vang, Zer Vue, Neng Vue, Andrea Marshall, Jennifer Gaddy, Celestine Wanjalla, Antentor Hinton Jr.*
Supported by the Cell Imaging Shared Resource.
Pharmacology- Functional specificity of liquid-liquid phase separation at the synapse. Nature Communications.
Natalie Guzikowski*, Ege Kavalali*.
School of Medicine Basic Sciences: How do you maintain a cellular structure without a membrane? Researchers find that synapses can use liquids to create functional separations
- Large variability in the alkaloid content of Corydalis yanhusuo dietary supplements. Frontiers in Pharmacology.
Paula Luis*, Claus Schneider*.
- Further Optimization of the mGlu1 PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685. ACS Chemical Neuroscience.
Carson Reed*, Jacob Kalbfleisch, Jeremy Turkett, Trevor Trombley, Paul Spearing, Daniel Haymer, Marc Quitalig, Jonathan Dickerson, Daniel Foster, Annie Blobaum, Olivier Boutaud, Hyekyung Cho, Colleen Niswender, Jerri Rook, Jeffrey Conn, Bruce Melancon, Craig Lindsley*.
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First or corresponding authors are identified with a *. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.
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