Vanderbilt University | School of Medicine – Basic Science

“The Reading List” in dark teal with a drawing, in gold tones, of a person with long hair, sitting cross legged and reading a book.

First authors are identified with an asterisk. Faculty with primary appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.

Week of December 4

Biochemistry

The multi-step oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive. Journal of Biological Chemistry.

Kevin McCarty*, Lu Liu*, Yasuhiro Tateishi, Hannah Wapshott-Stehli, F. Peter Guengerich.

Cell and Developmental Biology

Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults. Matrix Biology.

Elkie Peebles, Kimberly LaFever, Patrick Page-McCaw, Selene Colon, Aubrie Stricker, Gautam Bhave, Andrea Page-McCaw.
A framework to identify functional interactors that contribute to disrupted early retinal development in Vsx2 ocular retardation J mice. Developmental Dynamics.
Amanda Leung, Mahesh Rao, Nathan Raju, Minh Chung, Allison Klinger, DiAnna Rowe, Xiaodong Li, Edward Levine.

“Mutations in [VSX2] cause congenital [microphthalmia], disrupted [retina] architecture and [blindness]. Learn how [Mitf, RXR] and gamma-secretase expand and refine the Vsx2 interaction network in [retina neurogenesis] and development,” Developmental Dynamics.

Molecular Physiology and Biophysics

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts (preprint). bioRxiv.
Zer Vue*, Kit Neikirk, Larry Vang, Margaret Mungai, Andrea Marshall, Heather Beasley, Mason Killion, Remi Parker, Josephs Anukodem, Bret Mobley, Annet Kirabo, Yan Ru Su, Kelsey Tomasek, Xiuqi Zhang, Celestine Wanjalla, Antentor Hinton Jr.
Metaflammation in obesity and its therapeutic targeting. Science Translational Medicine.
Michael Schleh*, Heather Caslin, Jamie Garcia, Mona Mashayekhi, Gitanjali Srivastava, Anna Bradley, Alyssa Hasty.

“An exceptional review of how obesity revs up the immune system and inflammation, including what happens with weight regain,” Eric Topol.
A Microfluidic Platform for the Time-Resolved Interrogation of Polarized Retinal Pigment Epithelial Cells. Translational Vision Science and Technology.
Eric Spivey*, Jinggang Yin, Edward Chaum, John Wikswo.
BNIP3 as a new tool to promote healthy brain aging. Aging Cell.
Kit Neikirk, Andrea Marshall, Monica Santisteban, Antentor Hinton Jr.

Other Biomedical Basic Sciences Papers

The Antioxidative Effects of Flavones in Hypertensive Disease. Biomedicines.
Alexandria Porcia Haynes, Selam Desta, Taseer Ahmad, Kit Neikirk, Antentor Hinton Jr., Nathanial Bloodworth, Annet Kirabo.
A multicenter phase Ib trial of the histone deacetylase inhibitor entinostat in combination with pembrolizumab in patients with myelodysplastic syndromes/neoplasms or acute myeloid leukemia refractory to hypomethylating agents. Annals of Hematology.
Jan Philipp Bewersdorf (Yale School of Medicine), Silvia Park, Rahul Ramaswamy, Caroline Roe, Jonathan Irish, Tae Kon Kim.

Engineering Therapeutic Monoclonal Antibodies. Journal of Allergy and Clinical Immunology.

Cosby Stone, Benjamin Spiller, Scott Smith.

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Vanderbilt University School of Medicine Basic Sciences
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