Forwarded by the Los Angeles County Department of Public Health
Forwarded by the Los Angeles County Department of Public Health
CDC Health Advisory:
Mpox Caused by Human-to-Human Transmission of Monkeypox Virus with Geographic Spread in the Democratic Republic of the Congo 
December 07, 2023

The Centers for Disease Control and Prevention (CDC) has issued a health advisory today to notify clinicians about the occurrence, geographic spread, and sexually associated human-to-human transmission of Clade I Monkeypox virus (MPXV) in the Democratic Republic of the Congo (DRC). MPXV has two distinct genetic clades, and cases of Clade I MPXV have not been reported in the United States at this time (a clade is a broad grouping of viruses that has evolved over decades and is a genetic and clinically distinct group). The CDC asks clinicians to be aware of the possibility of Clade I MPXV in travelers who have been in DRC

Clinicians should notify their local public health department if they have a patient with mpox-like symptoms and recent travel to DRC. Public Health will coordinate MPXV clade-specific testing.
Los Angeles County DPH Division of HIV and STD Programs:
  • Weekdays 8:00 am–5:00 pm: call 213-368-7441.
  • After-hours: call 213-974-1234 and ask for the physician on call.
Long Beach Health and Human Services:
  • Weekdays 8:00 am-5:00 pm: call 562-570-4302.
  • After hours: call the duty officer at 562-500-5537.
Pasadena Public Health Department:
  • Weekdays 8:00 am-5:00 pm: call 626-744-6089.  
  • After hours: call 626-744-6043.
Vaccines (e.g., JYNNEOS, ACAM2000) and other medical countermeasures (e.g., tecovirimat, brincidofovir, and vaccinia immune globulin intravenous) are available and expected to be effective for both Clade I and Clade II MPXV infections. Clinicians should continue to encourage vaccination for patients who are eligible.
Visit the LAC DPH mpox provider hub for local resources related to vaccination, testing, treatment, and reporting.
Read the CDC Health Advisory
View as PDF
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