The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
Week of November 4
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By Basic Sciences department Biochemistry Cell and Developmental Biology- Temporal recording of mammalian development and precancer. Nature.
Mirazul Islam*, Yilin Yang, Alan Simmons, Vishal Shah, Yanwen Xu, Naila Tasneem, Zhengyi Chen, Linh Trinh, Paola Molina, Marisol Ramirez-Solano, Andrea Rolong, Mark Magnuson, Jeffrey Rathmell, Ian Macara, Qi Liu, Martha Shrubsole, Robert Coffey*, Ken Lau*.
Basic Sciences: Determining precise timing of cellular growth to understand the origins of cancer
GenomeWeb: Human Tumor Atlas Collection Reveals 3D Features of Cancer Tissue, Microenvironment
Nature: Ultra-precise 3D maps of cancer cells unlock secrets of how tumours grow
El País English: Largest cancer atlas to date brings new treatments for incurable tumors closer
New Scientist: Cancer atlas reveals how tumours evolve inside the body
Endpoint News: Atlas of tumors reveals in 3D how cells change into cancer
- Biofunctionalized gelatin hydrogels support development and maturation of iPSC-derived cortical organoids. Cell Reports.
Andrew Kjar*, Mia Haschert, José Zepeda, A. Joey Simmons, Alexis Yates, Daniel Chavarria, Melanie Fernandez, Gabriella Robertson, Adam Abdulrahman, Hyosung Kim, Nicole Marguerite, Rachel Moen, Lauren Drake, Corinne Curry, Brian O'Grady, Vivian Gama, Ken Lau, Brad Grueter, Jonathan Brunger, Ethan Lippmann*.
Supported by the Biomolecular NMR Facilty and the Cell Imaging Shared Resource research cores.
- Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse (preprint). bioRxiv.
Katrina Hofstetter*, Paula Haas, Jonathon Kuntz, Sabine Fuhrmann.
- New mutations in the core Schizosaccharomyces pombe spindle pole body scaffold Ppc89 reveal separable functions in regulating cell division. G3.
Sarah Hanna*, Bita Tavafoghi, Jun-Song Chen, Isaac Howard, Liping Ren, Alaina Willet, Kathleen Gould*.
- Molecular counting of myosin force generators in growing filopodia. Journal of Biological Chemistry.
Gillian Fitz, Matthew Tyska.
Molecular Physiology and Biophysics- The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy. Trends in Molecular Medicine.
Lay Shuen Tan* (Agency for Science, Technology and Research), Richard O'Brien.
- Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice. Nature Communications.
Cristiane dos Santos*, Amanda Cambraia*, Shristi Shrestha, Melanie Cutler, Matthew Cottam, Christopher Acree, Danielle Dean, Jean Philippe Cartailler, Rafael Arrojo e Drigo*.
Supported by the Creative Data Solutions research core.
- Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners. Molecular Metabolism.
Katie Coate*, Chunhua Dai*, Ajay Singh, Jade Stanley, Brittney Covington, Amber Bradley, Favour Oladipupo, Yulong Gong, Scott Wisniewski, Katelyn Sellick, Erick Spears, Greg Poffenberger, Anna Marie Schornack, Alexandria Bustabad, Tyler Rodgers, Nandita Dey, Alvin Powers*, Wenbiao Chen*, Danielle Dean*.
- Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations (preprint). bioRxiv.
Elysa Pierro, Matthew Cottam, Hanbing An, Brian Lehmann, Jennifer Pietenpol, Jeffrey Rathmell, Barbara Fingleton, Alyssa Hasty.
Supported by the Advanced Computing Center for Research and Education and the Vanderbilt Mouse Metabolic Phenotyping Center research cores.
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling. Nature Communications.
Ruojing Zhang*, Kevin Jagessar, Richard A. Stein, Erkan Karakas, Hassane Mchaourab*.
Supported by the Cryo-EM Facility research core.
- Endothelial Beta 1 Integrins are Necessary for Microvascular Function and Glucose Uptake. American Journal of Physiology-Endocrinology and Metabolism.
Nathan Winn*, Deborah Roby, Penn Mason McClatchey, Ian Williams, Deanna Bracy, Michelle Bedenbaugh, Louise Lantier, Erin Plosa, Ambra Pozzi, Roy Zent, David Wasserman.
Supported by the Vanderbilt Mouse Metabolic Phenotyping Center research core.
- Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure. Circulation Research.
Mohammad Saleem, Luul Aden, Ashley Mutchler, Chitra Basu, Lale Ertuglu, Quanhu Sheng, Jennifer Park, Jeanne Ishimwe, Cheryl Laffer, Celestine Wanjalla, Nestor de la Visitacion, Paul Kastner, Claude Albritton, Taseer Ahmad, Alexandria Haynes, Justin Yu, Meghan Graber, Sharia Yasmin, Antonis Hatzopoulos, Eric Gamazon, Alexander Bick, Annet Kirabo.
VUMC News: Clue to salt-sensitive blood pressure found
- Defining unique structural features in the MAFA and MAFB transcription factors that control Insulin gene activity. Journal of Biological Chemistry.
Jeeyeon Cha, Xin Tong, Katie Coate, Min Guo, Jin-hua Liu, Garrett Reynolds, Richard Stein, Hassane Mchaourab, Roland Stein.
Pharmacology
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First or corresponding authors are identified with a *. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.
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