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Vanderbilt University | School of Medicine – Basic Science

The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.

Week of July 28

Department of Biochemistry

A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines. European Journal of Human Genetics.
Susan White* (Murdoch Children's Research Institute), Areetha D'Souza, Walter Chazin.

Department of Cell and Developmental Biology

Apical clathrin-coated pits control the location, timing, and scale of microvillar growth. Cell Reports.
Olivia Perkins*, Alexandra Mulligan, Evan Krystofiak, K. Elkie Peebles, Rekha Nagarajan, Leslie Meenderink, Bryan Millis, Matthew Tyska*.

Supported by the Cell Imaging Shared Resource.
Single Cell Profiling in the Sox10^Dom Hirschsprung Mouse Implicates Hox genes in Enteric Neuron Trajectory Allocation. Cellular and Molecular Gastroenterology and Hepatology.
Justin Avila*, Joseph Benthal*, Jenny Schafer, David Flaherty, Michelle Southard-Smith*.

Supported by the Cell Imaging Shared Resource.
Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors. Nature Communications.
Monica Brown*, Verda Miranda*, Simone Nevills*, Ruiying Hu*, Prasanna Dadi, Alan Simmons, Yanwen Xu, Yilin Yang, Mahircan Yagan, Sadia Najam, Leesa Sampson, Mark Magnuson, David Jacobson, Ken Lau*, Emily Hodges*, Guoqiang Gu*.

School of Medicine Basic Sciences: New research points to cell subtypes that increase risk of diabetes

Department of Molecular Physiology and Biophysics

Glucokinase Activators. A Humbling Lesson in Drug Development. Diabetes.
Loranne Agius* (Newcastle University), Mark Magnuson*.
Tensor decomposition of multi-dimensional splicing events across multiple tissues to identify splicing-mediated risk genes associated with complex traits. PLOS Computational Biology.
Yan Yan*, Rui Chen*, Hakmook Kang, Yuting Tan, Anshul Tiwari, Siyuan Ma, Xue Zhong, Bingshan Li*.

Department of Pharmacology

Profiling the Impact of mGlu₇/Elfn1 Protein Interactions on the Pharmacology of mGlu₇ Allosteric Modulators. ACS Chemical Neuroscience.
Xia Lei*, Zixiu Xiang, Alice Rodriguez, Margaret Wilson, Colleen Niswender*.

Other basic biomedical papers

Neuron-to-glia signaling drives critical period experience-dependent synapse pruning. Scientific Reports.
Nichalas Nelson*, Kendal Broadie*.

First or corresponding authors are identified with an *. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.

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