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Moores Members Erik N. Bergstrom, PhD and Ludmil B. Alexandrov, PhD have developed an AI tool, DeepHRD, which can detect DNA repair problems quickly and accurately in breast, ovarian, and other cancers by analyzing routine biopsy images. Learn More>>

Moores Associate Director for Translational Research, Gene Yeo, PhD, MBA, led a team of scientists who observed that as brain cells age, they undergo stress and changes that may make them more susceptible to diseases such as Alzheimer’s and ALS. Learn More>>

The Sandbox is a research facility at UC San Diego designed to centralize scientific instruments and foster interdisciplinary collaboration across the biological and medical sciences. Sandbox Faculty Director and Moores Member, Uri Manor, PhD, sees the Sandbox as a space in which scientists from diverse fields can “play” together using advanced tools, which can engender transformative discoveries from molecules to cells. Learn More>>

RMAS Grand Rounds allows participants to expand knowledge, engage in interdisciplinary discussions, and stay abreast of advancements in radiation therapy. On June 26, 2025, Kelly Kisling, PhD will present "From Global Outreach to Local Care: Three Perspectives on the Expanding Role of Medical Physics." RSVP Now>>

Journal of Clinical Oncology

Lyudmila Bazhenova, MD (Solid Tumor Therapeutics)

Nature Communications

Dale M. Anders, PhD (Solid Tumor Therapeutics)

Hepatology

Rohit Loomba, MD (Cancer Control)

10629: A Phase I Dose Finding and Phase II Randomized Trial of Iadademstat Combined with Immune Checkpoint Inhibition Maintenance After Initial Chemoimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer

PI: Lyudmila Bazhenova, MD

NCT ID: NCT06287775

 

A2B395-101: A Seamless Phase I/II Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated T-mod CAR T, in Heterozygous HLAA02 Adults with Recurrent Unresectable, Locally Advanced, or Metastatic Solid Tumors That Express EGFR and Have Lost HLAA02 Expression

PI: Rebecca Shatsky, MD

NCT ID: NCT06682793

 

STML-ELA-0422: Elacestrant Versus Standard Endocrine Therapy in Women and Men with Node-positive, Estrogen Receptor-positive, HER2negative, Early Breast Cancer with High Risk of Recurrence: A Global, Multicenter, Randomized, Open-label Phase III Study

PI: Rebecca Shatsky, MD

NCT ID: NCT06492616

 

ALN-BCAT-001: A Phase I Study of ALNBCAT as Monotherapy and in Combination with Pembrolizumab in Patients with Advanced or Metastatic Hepatocellular Carcinoma

PI: Adam Burgoyne, MD

NCT ID: NCT06600321

 

10466: A Phase II Study of Bevacizumab, Erlotinib, and Atezolizumab in Subjects with Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Associated or Sporadic Papillary Renal Cell Cancer

PI: Rana McKay, MD

NCT ID: NCT04981509

 

NKT2152-101: Phase I/II Open Label Dose-escalation and Expansion Trial of NKT2152, an Orally Administered HIF2 Inhibitor, to Investigate Safety Pharmacokinetics Pharmacodynamics and Clinical Activity in Patients with Advanced Clear Cell Renal Cell Carcinoma

PI: Rana McKay, MD

NCT ID: NCT05119335

 

BH-30643-01: A Phase I/II Open-Label, Multicenter, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of BH30643 in Adult Subjects with Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations (SOLARA)

PI: Lyudmila Bazhenova, MD

NCT ID: NCT06706076

 

10636: Phase I Trial of CA4948 in Combination with Pembrolizumab to Overcome Resistance to PD1/PDL1 Blockade in Metastatic Urothelial Cancer

PI: Tyler Stewart, MD

NCT ID: NCT06439836

The Researcher Spotlight is designed to help you connect with fellow researchers, gain insights into their diverse projects, and discover the paths that led them to their current roles. Uncover a personal touch to their professional achievements, showcasing the varied perspectives within our cancer research community.

Gene Yeo, PhD, MBA, is a Professor of Cellular and Molecular Medicine at the University of California San Diego, Director for UC San Diego’s Center for RNA Technologies and Therapeutics, Chief Scientific Advisor for Sanford Laboratories for Innovative Medicine and Director for the Sanford Stem Cell Institute’s Innovation Center. He is also the Associate Director for Translational Science at Moores Cancer Center. Dr. Yeo is a computational and experimental scientist who studies how RNA processing is regulated by RNA binding proteins in development and disease.

Department of Research Administration

3855 Health Sciences Drive, La Jolla, CA 92037

moorescancercenter.ucsd.edu

 

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