Recently published

• Bioinformatics Screen Reveals Gli-Mediated Hedgehog Signaling as an Associated Pathway to Poor Immune Infiltration of Dedifferentiated Liposarcoma. Cancers.
  Erik Beadle, Natalie Bennett, Julie Rhoades.
  
  
• Oxidative stress drives mutagenesis through transcription-coupled repair in bacteria. Proceedings of the National Academ of Sciences.
  Juan Carvajal-García, Ariana Samadpour, Angel Hernandez Viera, Houra Merrikh.
  
  “Here we show that 1) Endogenous oxidative stress drives the evolution of antibiotic resistance, 2) This is dependent on mutations caused by transcription-coupled repair … and 3) Replicative and trans-lesion synthesis polymerases are responsible for the mutagenesis!” Juan Carvajal García.
  
  
• Antioxidant Flavonoid Diosmetin Is Cardioprotective in a Rat Model of Myocardial Infarction Induced by Beta 1-Adrenergic Receptors Activation. Current Issues in Molecular Biology.
  Taseer Ahmad (COMSATS University Islamabad), Annet Kirabo.
  
  
• 3,4-Desaturation of retinoic acid by cytochrome P450 27C1 prevents P450-mediated catabolism. Archives of Biochemistry and Biophysics.
  Sarah Glass, Yasuhiro Tateishi, Fred Guengerich, Hong-Jaan Wang.
  
  
• Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes & Development.
  Vladimir Abarinov (Columbia University), Mark Magnuson.
  
  
• GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements. Cells.
  Chen Zheng, Liana Weinstein, Kevin Nguyen, Abhijeet Grewa,
  Eugenia Gurevich, Vsevolod Gurevich.
  
  
• Mechanisms of Arrestin-Mediated Signaling. Current Protocols.
  Vsevolod Gurevich, Eugenia Gurevich.
  
  
• MitoTrace: A Computational Framework for Analyzing Mitochondrial Variation in Single-Cell RNA Sequencing Data. Genes.
  Mingqiang Wang (The University of Texas Health Science Center at Houston), David Samuels, Zhongming Zhao.
  
  
• 100 years of glucagon and 100 more. Diabetologia.
  Nicolai Wewer Albrechtsen (University of Copenhagen), Alan Cherrington, Danielle Dean.
  
  
• Extracellular matrix remodelling in obesity and metabolic disorders. Life Metabolism.
  Vishal Musale (University of Dundee), David Wasserman.
  

Preprints

• Alterations in Cardiovascular and Cerebral Pulse Wave Velocity in 5XFAD Murine Model of Alzheimer’s Disease. bioRxiv.
  Andrea Marshall, Kit Neikirk, Taylor Barongan, Bryanna Shao, Amber Crabtree, Dominique Stephens, Zer Vue, Heather Beasley, Jose Gomez, Antentor Hinton Jr.
  
  
• The broad impact of cell death genes on the human disease phenome. medRxiv.
  Abigail Rich, Phillip Lin, Eric Gamazon, Sandra Zinkel.
  
  
• The MODY-associated TALK-1 L114P mutation causes islet α-cell overactivity and β-cell inactivity resulting in transient neonatal diabetes and glucose dyshomeostasis in adults. bioRxiv.
  Arya Nakhe, Prasanna Dadi, Jinsun Kim, Shristi Shrestha, Jean-Philippe Cartailler, Leesa Sampson, Mark Magnuson, David Jacobson.
  

Highlighted across the web

• CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth. Molecular Cancer.
  Jinming Yang, Kensie Bergdorf, Chi Yan, Weifeng Luo, Sheau-Chiann Chen, Gregory Ayers, Qi Liu, Xiao Liu, Mark Boothby, Vivian Weiss, Sarah Groves, Austin Oleskie, Vito Quaranta, Ann Richmond.
  
  Highlighted in the VUMC Reporter.
  
  
• SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. The Journal of Clinical Investigation.
  Jennifer Pilat, Rachel Brown, Zhengyi Chen, Nathaniel Berle, Adrian Othon, M. Kay Washington, Shruti Anant, Victoria Ng, Joshua Thompson, Justin Jacobse, Jeremy Goettel, Ethan Lee, Yash Choksi, Ken Lau, Sarah Short, Christopher Williams.
  
  Highlighted in the VUMC Reporter.
  
  

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