Recently published

• An evolving view of Complex II – non-canonical complexes, megacomplexes, respiration, signaling, and beyond. Journal of Biological Chemistry.
  Tina Iverson, Prashant Singh.
  
  
• Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies. eLife.
  Taylor Engdahl, Elad Binshtein, Nathaniel Chapman, Monique Porter, Laura Handal, Summer Diaz, Irene Zagol-Ikapitte, Minh Tran, Hayes McDonald, Jens Meiler, Joseph Reidy, Andrew Trivette, James Crowe.
  
  “We describe four sites of vulnerability on the Gn/Gc spike targeted by neutralizing antibodies,” Taylor Engdahl.
  
  
• Computational modeling and prediction of deletion mutants. Structure.
  Hope Woods, Dominic Schiano, Jonathan Aguirre, Kaitlyn Ledwitch, Eli McDonald, Markus Voehler, Jens Meiler, Clara Schoeder.
  
  “The [Jens Meiler lab] investigates the effects of in frame deletion mutants on a small alpha-helical protein and finds that a combo of [AlphaFold 2] & [Rosetta] can correctly classify most deletion mutants tested,” Vanderbilt Center for Structural Biology.
  
  
• Application of a quantitative framework to improve the accuracy of a bacterial infection model. Proceedings of the National Academy of Sciences.
  Gina Lewin (Georgia Institute of Technology), Simone Harrison, Eric Skaar, Walter Chazin.
  
  “We propose & validate two general approaches for improving laboratory models: 1. combine models that are accurate in different ways 2. mine publicly available sequencing data to identify a condition that corrects the accuracy of target genes,” Gina Lewin.
  
  
• Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease. Investigative Ophthamology & Visual Science.
  Mark Derbyshire (Upstate Medical University), Sabine Fuhrmann.
  
  
• A Comprehensive Approach to Sample Preparation for Electron Microscopy and the Assessment of Mitochondrial Morphology in Tissue and Cultured Cells. Advanced Biology.
  Antentor Hinton Jr., Kit Neikirk, Bryanna Shao, Zer Vue, Larry Vang, Heather Beasley, Andrea Marshall, Dominique Stephens, Steven Damo.
  
  
• A junction-dependent mechanism drives murine mammary cell intercalation for ductal elongation. Developmental Cell.
  Alexander Pfannenstein, Ian Macara. 
  
  
• GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders. Neuropharmacology.
  Ferdinando Nicoletti (Sapienza University of Rome), Jeffrey Conn, Shalini Dogra.
  
  
• Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex. Chemical Communications.
  Dhrubajyoti Datta (Alnylam Pharmaceuticals), Martin Egli.
  
  
• Base excision repair of the N-(2-deoxy-D-erythr-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase. Nucleic Acids Research.
  Rachana Tomar, Pankaj Sharma, Andrew Kellum Jr, Li Lei, Joel Harp, Tina Iverson, Martin Egli, Michael Stone.
  
  “This study sheds light on the mechanism of hNEIL1 function between different DNA lesions and provides a basis for further research in base excision repair pathways,” Weekly Coordinates.
  

Preprints

• Distinct CD3+ CD14+ T Cell-Monocytes are dynamic complexes that harbor HIV and are increased with glucose intolerance. bioRxiv.
  Celestine Wanjalla, Joshua Simmons, Jared Oakes, Xiuqi Zhang, Cindy Nochowicz, Stephen Priest, Samuel Bailin, Mona Mashayekhi, Heather Beasley, Leslie Meenderink, Quanhu Sheng, Joey Stolze, Rama Gangula, Curtis Gabriel, Suman Pakala, Erin Wilfong, Elizabeth Phillips, David Harrison, Antentor Hinton Jr., Spyros Kalams, Simon Mallal, John Koethe.
  

Highlighted across the web

• Development of Pluoronic nanoparticles of fluorocoxib A for endoscopic fluorescence imaging of colonic adenomas. SPIE Digital Library. Journal of Biomedical Optics.
  Md Jashim Uddin, Hiroaki Niitsu, Robert Coffey, Lawrence Marnett.
  Highlighed in the VUMC Reporter.
  

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